Cortical plasticity between the pain and pain-free phases in patients with episodic tension-type headache.
Cortical plasticity between the pain and pain-free phases in patients with episodic tension-type headache.
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发作性张力型头痛患者的疼痛和无疼痛相之间的皮质可塑性。
DOI：
10.1186/s10194-016-0698-6
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Zheng JL
中科院分区：
文献类型：
--
作者：
Chen B;He Y;Xia L;Guo LL;Zheng JL
发作性紧张型头痛（ETTH）患者的状态相关脑结构改变尚不清楚。我们的目的是进行一项纵向研究，探讨动态灰质（GM）的变化之间的疼痛和无痛阶段的ETTH。我们招募了40名未经治疗的ETTH患者和40名健康对照。所有参与者在3.0-T MRI系统上进行脑结构扫描。ETTH患者在疼痛阶段和疼痛阶段进行扫描。基于体素的形态学分析用于确定组间区域灰质密度（GMD）的差异。使用额外的回归分析来确定区域GMD和临床症状之间的任何关联。ETTH患者在疼痛阶段与疼痛阶段相比，双侧初级躯体感觉皮层的GMD减少，双侧前扣带皮层（ACC）和前扣带皮层的GMD增加。与健康对照组相比，ETTH患者的疼痛期没有表现出较高或较低的GMD区域。左侧ACC和左前额叶GMD与头痛天数呈负相关。ETTH患者左侧ACC GMD与焦虑、抑郁症状呈负相关。这是第一项研究，以证明动态和可逆的GMD变化之间的疼痛和疼痛阶段的ETTH患者。然而，这种平衡可能会被头痛天数的增加和进行性焦虑和抑郁症状所破坏。
State-related brain structural alterations in patients with episodic tension-type headache (ETTH) are unclear. We aimed to conduct a longitudinal study to explore dynamic gray matter (GM) changes between the pain and pain-free phases in ETTH. We recruited 40 treatment-naïve ETTH patients and 40 healthy controls. All participants underwent brain structural scans on a 3.0-T MRI system. ETTH patients were scanned in and out of pain phases. Voxel-based morphometry analysis was used to determine the differences in regional gray matter density (GMD) between groups. Additional regression analysis was used to identify any associations between regional GMD and clinical symptoms. ETTH patients exhibited reduced GMD in the bilateral primary somatosensory cortex, and increased GMD in the bilateral anterior cingulate cortex (ACC) and anterior insula for the in pain phase compared with the out of pain phase. The out of pain phase of ETTH patients exhibited no regions with higher or lower GMD compared with healthy controls. GMD in the left ACC and left anterior insula was negatively correlated with headache days. GMD in the left ACC was negatively correlated with anxiety and depressive symptoms in ETTH patients. This is the first study to demonstrate dynamic and reversible GMD changes between the pain and pain-free phases in ETTH patients. However, this balance might be disrupted by increased headache days and progressive anxiety and depressive symptoms.
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DOI：
10.1016/j.nicl.2014.10.003
发表时间：
2014
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Naegel S;Holle D;Desmarattes N;Theysohn N;Diener HC;Katsarava Z;Obermann M
通讯作者：
Obermann M
DOI：
10.1073/pnas.96.14.7705
发表时间：
1999-07-06
影响因子：
11.1
作者：
Bushnell, MC;Duncan, GH;Carrier, B
通讯作者：
Carrier, B
影响因子：
4.9
作者：
Coppola, Gianluca;Di Renzo, Antonio;Pierelli, Francesco
通讯作者：
Pierelli, Francesco
影响因子：
7.4
作者：
PRICE, DD;BUSH, FM;HARKINS, SW
通讯作者：
HARKINS, SW
影响因子：
14.5
作者：
Gu, Xiaosi;Gao, Zhixian;Fan, Jin
通讯作者：
Fan, Jin