Cortical plasticity in episodic and chronic cluster headache.
Cortical plasticity in episodic and chronic cluster headache.
复制标题
DOI：
10.1016/j.nicl.2014.10.003
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Obermann M
中科院分区：
文献类型：
--
作者：
Naegel S;Holle D;Desmarattes N;Theysohn N;Diener HC;Katsarava Z;Obermann M
丛集性头痛 (CH) 的特点是反复发作极度疼痛的单侧头痛，通常伴有三叉神经自主神经症状。由于其节奏与疼痛和无痛交替发作，它是一个很好的模型，用于研究基于磁共振的基于体素的形态测量（VBM）检测到的大脑结构变化是否反映了疾病的原因，是否可能是除疼痛之外的潜在疾病的结果，或者可能仅仅是由疼痛本身的感觉引起的。我们使用 VBM 调查了 91 名处于不同疾病阶段的 CH 患者，并将他们与 78 名年龄和性别匹配的健康对照进行了比较。我们检测到不同大脑区域（包括颞叶、海马体、岛叶皮质和小脑）存在明显的区域灰质（GM）变化。观察到的 GM 改变的程度、位置和方向取决于疾病状态，并且与疼痛状态（即疼痛与无痛）相关，呈动态变化。与健康对照相比，CH 患者未检测到下丘脑变化。本研究中观察到的 GM 变化是高度动态的，从而反映了大脑在疼痛方面的皮质可塑性。这种观察到的动态可能为之前 VBM 研究疼痛的不同结果提供了解释。关于CH，结果表明该疾病更可能是由网络功能障碍而不是单一结构故障引起的。我们发现，与健康对照组相比，丛集性头痛 (CH) 患者的疼痛处理区域及其他部位的灰质 (GM) 发生变化，不同病程（慢性、阵发性内部发作、阵发性外部发作）的 GM 变化存在显着差异。 GM 降低主要在慢性 CH 中观察到，而阵发性 CH 表现出更复杂且部分相反的行为。这种动态可能反映了大脑对皮质可塑性变化刺激的适应能力，并可能为先前 VBM 研究疼痛的不同结果提供解释
Cluster headache (CH) is characterized by recurrent episodes of excruciatingly painful, unilateral headache attacks typically accompanied by trigeminal autonomic symptoms. Due to its rhythm with alternating episodes of pain and no-pain, it is an excellent model to investigate whether structural brain changes detected by magnetic resonance based voxel-based-morphometry (VBM) reflect the cause of the disease, may be a consequence of the underlying disease other than pain, or may simply be caused by the sensation of pain itself. We investigated 91 patients with CH in different stages of their disease using VBM and compared them to 78 age- and gender-matched healthy controls. We detected distinct regional gray matter (GM) changes in different brain regions including the temporal lobe, the hippocampus, the insular cortex and the cerebellum. The extent, location and direction of observed GM alterations depended on the state of disease and appeared dynamic in relation to pain state (i.e., pain vs. no-pain). No hypothalamic changes were detected in CH patients compared to healthy controls. The GM changes observed in this study are highly dynamic and thereby reflect the cortical plasticity of the brain in regard to pain. This observed dynamic may provide an explanation of the diverse results of previous VBM studies in pain. Regarding CH the results suggest that the disease is more likely to be caused by a network dysfunction rather than by a single malfunctioning structure. We identified gray matter (GM) changes in pain processing areas and beyond in patients suffering cluster headache (CH) compared to healthy controls GM changes significantly differed for different courses of the disease (chronic, episodic inside bout, episodic outside bout). GM decrease was predominantly observed in chronic CH, while episodic CH showed a more complex and partly opposite behavior. This dynamic probably reflects the brain's adaptation capacity to changing stimuli in regard to cortical plasticity and may provide an explanation of the diverse results of previous VBM studies in pain
登录
查看更多内容
影响因子：
7.4
作者：
Antonaci, Fabio;Nappi, Giuseppe;Galli, Federica;Manzoni, Gian Camillo;Calabresi, Paolo;Costa, Alfredo
通讯作者：
Costa, Alfredo
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
11.2
作者：
Holle, Dagny;Naegel, Steffen;Obermann, Mark
通讯作者：
Obermann, Mark
影响因子：
2.5
作者：
Coghill, RC;Gilron, I;Iadarola, MJ
通讯作者：
Iadarola, MJ
影响因子：
5.3
作者：
Boyke, Janina;Driemeyer, Joenna;May, Arne
通讯作者：
May, Arne