Hippocampal place cell sequences differ during correct and error trials in a spatial memory task.
Hippocampal place cell sequences differ during correct and error trials in a spatial memory task.
复制标题
在空间记忆任务的正确和错误试验中，海马位置细胞序列有所不同
DOI：
10.1038/s41467-021-23765-x
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发表时间：
2021-06-07
影响因子：
16.6
通讯作者：
Colgin LL
中科院分区：
文献类型：
--
作者：
Zheng C;Hwaun E;Loza CA;Colgin LL
Theta节律在活跃行为期间在时间上协调海马位置细胞集合序列，而在休息期间协调位置细胞序列的尖波波纹。我们研究了这种协调海马位置细胞序列是否在延迟匹配到位置任务的错误试验期间被破坏。由于奖励位置是在试验中学习的，因此开发了位置单元序列，该序列表示在接近奖励位置的过程中到达奖励位置的时间压缩路径。当接近不正确的停止位置时，在错误试验上表示压缩较少的路径。在休息期间的正确，但不是错误的试验，位置细胞序列开发了一个偏见，以重放表示的路径结束在正确的奖励位置。这些结果支持的假设，协调的位置细胞序列的θ节奏和尖锐的波浪涟漪发展作为奖励位置的学习，并可能是重要的空间记忆任务的成功执行。在这里，作者比较了在空间记忆任务中正确和错误试验期间的位置细胞序列编码。序列编码的路径是更长的时间和更多的时间压缩在正确的试验，并制定了一个偏见，重放路径的目标位置在休息期间的正确，但不是错误的试验。
Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles during active behaviors, while sharp wave-ripples coordinate place cell sequences during rest. We investigated whether such coordination of hippocampal place cell sequences is disrupted during error trials in a delayed match-to-place task. As a reward location was learned across trials, place cell sequences developed that represented temporally compressed paths to the reward location during the approach to the reward location. Less compressed paths were represented on error trials as an incorrect stop location was approached. During rest periods of correct but not error trials, place cell sequences developed a bias to replay representations of paths ending at the correct reward location. These results support the hypothesis that coordination of place cell sequences by theta rhythms and sharp wave-ripples develops as a reward location is learned and may be important for the successful performance of a spatial memory task. Here the authors compare place cell sequence coding during correct and error trials in a spatial memory task. Sequences coded paths that were longer and more temporally compressed during correct trials and developed a bias to replay paths to a goal location during rest periods of correct but not error trials.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
3.5
作者：
Buzsáki, G
通讯作者：
Buzsáki, G
影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
影响因子：
3.5
作者：
Foster, David J.;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G