SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.
SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.
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DOI：
10.1038/s41586-022-04441-6
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
Kawaoka Y
中科院分区：
文献类型：
--
作者：
Halfmann PJ;Iida S;Iwatsuki-Horimoto K;Maemura T;Kiso M;Scheaffer SM;Darling TL;Joshi A;Loeber S;Singh G;Foster SL;Ying B;Case JB;Chong Z;Whitener B;Moliva J;Floyd K;Ujie M;Nakajima N;Ito M;Wright R;Uraki R;Warang P;Gagne M;Li R;Sakai-Tagawa Y;Liu Y;Larson D;Osorio JE;Hernandez-Ortiz JP;Henry AR;Ciuoderis K;Florek KR;Patel M;Odle A;Wong LR;Bateman AC;Wang Z;Edara VV;Chong Z;Franks J;Jeevan T;Fabrizio T;DeBeauchamp J;Kercher L;Seiler P;Gonzalez-Reiche AS;Sordillo EM;Chang LA;van Bakel H;Simon V;Consortium Mount Sinai Pathogen Surveillance (PSP) study group;Douek DC;Sullivan NJ;Thackray LB;Ueki H;Yamayoshi S;Imai M;Perlman S;Webby RJ;Seder RA;Suthar MS;García-Sastre A;Schotsaert M;Suzuki T;Boon ACM;Diamond MS;Kawaoka Y
最近出现的B.1.1.529，即Omicron变体，引起了人们对逃避疫苗和治疗性抗体保护的担忧。针对B.1.1.529的潜在对策的关键测试是其在呼吸道疾病的临床前啮齿动物模型中的活性。在这里，我们利用国家过敏和传染病研究所（NIAID）的SARS-CoV-2病毒进化评估（SAVE）计划的协作网络，评估了几种B.1.1.529分离株在免疫正常和人类表达ACE2 （hACE2）的小鼠和仓鼠中引起感染和疾病的能力。尽管建模数据表明B.1.1.529尖峰更容易与小鼠ACE2结合（参考文献）。)，我们观察到B.1.1.529在129、C57BL/6、BALB/c和K18-hACE2转基因小鼠中的感染率低于先前的SARS-CoV-2变体，体重减轻有限，上呼吸道和下呼吸道的病毒负荷较低。在野生型和hACE2转基因仓鼠中，与历史分离株或其他关注的SARS-CoV-2变体相比，B.1.1.529的肺部感染、临床疾病和病理也较轻。总体而言，来自SAVE/NIAID网络的几个B.1.1.529分离株的实验表明，啮齿动物的肺部疾病减轻，这与初步的人类临床数据相似。一项合作研究表明，与以前的SARS-CoV-2变体相比，B.1.1.529分离株在小鼠和仓鼠中引起的感染和疾病较少，这与人类研究的初步数据一致。
The recent emergence of B.1.1.529, the Omicron variant, has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. ), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data. A collaborative study demonstrates that, compared with previous SARS-CoV-2 variants, B.1.1.529 isolates cause less infection and disease in mice and hamsters, in agreement with preliminary data from studies in humans.
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影响因子：
64.8
作者：
Barnes CO;Jette CA;Abernathy ME;Dam KA;Esswein SR;Gristick HB;Malyutin AG;Sharaf NG;Huey-Tubman KE;Lee YE;Robbiani DF;Nussenzweig MC;West AP Jr;Bjorkman PJ
通讯作者：
Bjorkman PJ
DOI：
10.1093/infdis/jiab587
发表时间：
2022-01-18
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Halfmann PJ;Nakajima N;Sato Y;Takahashi K;Accola M;Chiba S;Fan S;Neumann G;Rehrauer W;Suzuki T;Kawaoka Y
通讯作者：
Kawaoka Y
DOI：
10.1126/science.abc4730
发表时间：
2020-09-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gu H;Chen Q;Yang G;He L;Fan H;Deng YQ;Wang Y;Teng Y;Zhao Z;Cui Y;Li Y;Li XF;Li J;Zhang NN;Yang X;Chen S;Guo Y;Zhao G;Wang X;Luo DY;Wang H;Yang X;Li Y;Han G;He Y;Zhou X;Geng S;Sheng X;Jiang S;Sun S;Qin CF;Zhou Y
通讯作者：
Zhou Y
影响因子：
16.6
作者：
Jangra, Sonia;De Vrieze, Jana;Schotsaert, Michael
通讯作者：
Schotsaert, Michael
影响因子：
7.6
作者：
Abdelnabi R;Foo CS;Zhang X;Lemmens V;Maes P;Slechten B;Raymenants J;André E;Weynand B;Dallmeier K;Neyts J
通讯作者：
Neyts J