SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters.

SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters.
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SARS-CoV-2对叙利亚仓鼠体内流感病毒复制的干扰。

DOI:
10.1093/infdis/jiab587
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发表时间:
2022-01-18
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Kawaoka Y
Kawaoka Y
中科院分区:
其他
文献类型:
--
作者:
Halfmann PJ;Nakajima N;Sato Y;Takahashi K;Accola M;Chiba S;Fan S;Neumann G;Rehrauer W;Suzuki T;Kawaoka Y

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在仓鼠中,在H3 N2流感病毒感染的同时或之前感染SARS-CoV-2导致肺和鼻甲中流感病毒滴度显著降低。这种干扰可能与SARS-CoV-2诱导的MX 1表达有关。在仓鼠中,先前感染严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)会干扰流感病毒(H3 N2亚型)的连续感染。SARS-CoV-2感染诱导的干扰素刺激基因MX 1的诱导可能在对该流感亚型的干扰中发挥部分作用。
In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2–induced expression of MX1. In hamsters, a previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interferes with a sequential infection with influenza virus (H3N2 subtype). The induction of the interferon-stimulated gene MX1induced by SARS-CoV-2 infection may play a partial role in the interference with this influenza subtype.
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