Neurophysiological abnormalities in the sensorimotor cortices during the motor planning and movement execution stages of children with cerebral palsy.
Neurophysiological abnormalities in the sensorimotor cortices during the motor planning and movement execution stages of children with cerebral palsy.
复制标题
DOI：
10.1111/dmcn.12513
复制
发表时间：
2014-11
影响因子：
3.8
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Kurz MJ;Becker KM;Heinrichs-Graham E;Wilson TW
本研究采用脑磁图（MEG）技术，对典型发育儿童和脑瘫儿童在运动计划和运动执行阶段的感觉运动皮层神经振荡反应进行了研究。该研究涉及13名CP儿童（9名男性，4名女性;平均[SD]年龄14岁3个月[9个月]，范围10- 18岁;身高1.61 m [0.08 m];体重52.65 kg [13 kg]）和13名年龄和性别匹配的典型发育儿童（身高1.64 m [0.06 m];体重56.88 kg [10 kg]）。该实验要求儿童伸展膝关节，同时获得全头MEG记录。采用Beamformer成像方法量化在运动计划阶段发生的β频率（14- 28 Hz）事件相关去同步化（ERD）和在运动执行阶段发生的γ频率（~ 50 Hz）事件相关同步化（ERS）的源活动。CP儿童在运动计划阶段的平均β ERD较强，在运动开始时的平均γ ERS较低。CP儿童的非特征性β ERD表明他们可能在计划膝关节运动方面有更大的困难。我们认为，这些异常的β ERD振荡可能会对γ ERS产生级联效应，最终影响电机命令的执行。
This investigation used magnetoencephalography (MEG) to examine the neural oscillatory responses of the sensorimotor cortices during the motor planning and movement execution stages of children with typical development and children with cerebral palsy (CP). The study involved 13 children with CP (nine males, four females; mean [SD] age 14y 3mo [9mo], range 10–18y; height 1.61m [0.08m]; weight 52.65kg [13kg]), and 13 age- and sex-matched children with typical development (height 1.64m [0.06m]; weight 56.88kg [10kg]). The experiment required the children to extend their knee joint as whole-head MEG recordings were acquired. Beamformer imaging methods were employed to quantify the source activity of the beta-frequency (14–28Hz) event-related desynchronization (ERD) that occurs during the motor planning period, and the gamma-frequency (~50Hz) event-related synchronization (ERS) that occurs at the motor execution stage. The children with CP had a stronger mean beta ERD during the motor planning phase and reduced mean gamma ERS at the onset of movement. The uncharacteristic beta ERD in the children with CP suggests that they may have greater difficulty planning knee joint movements. We suggest that these aberrant beta ERD oscillations may have a cascading effect on the gamma ERS, which ultimately affects the execution of the motor command.
登录
查看更多内容
影响因子：
2
作者：
Mutsaarts, Marcel;Steenbergen, Bert;Bekkering, Harold
通讯作者：
Bekkering, Harold
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
2.5
作者：
Kurz, Max J.;Wilson, Tony W.
通讯作者：
Wilson, Tony W.
影响因子：
4.7
作者：
Pfurtscheller, G;Graimann, B;Schuh, LA
通讯作者：
Schuh, LA
影响因子：
1.7
作者：
DeLuca, PA;Ounpuu, S;Walsh, JHP
通讯作者：
Walsh, JHP