Maternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study.
Maternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study.
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DOI：
10.1177/1362361319877792
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发表时间：
2020-07
期刊：
影响因子：
5.2
通讯作者：
Schmidt, Rebecca J.
中科院分区：
文献类型：
--
作者：
Huang, Yunru;Iosif, Ana-Maria;Hansen, Robin L.;Schmidt, Rebecca J.
先前的研究表明，母体多不饱和脂肪酸（PUFA）可能对神经发育结果具有保护作用。在前瞻性队列中研究母亲怀孕期间多不饱和脂肪酸摄入量与自闭症谱系障碍 (ASD) 和其他非典型发育 (Non-TD) 风险之间的关联。符合条件的女性已经生育了患有自闭症谱系障碍的孩子，并且正在计划怀孕或怀有另一个孩子。对儿童进行纵向临床评估并在 36 个月时诊断。使用食物频率调查问卷估算母亲在怀孕期间的多不饱和脂肪酸摄入量。通过气相色谱法测量母亲妊娠晚期血浆 PUFA 浓度。其中包括 258 对母子。在怀孕后半段摄入更多 omega3 总量的母亲，生出患有自闭症谱系障碍 (ASD) 的孩子的可能性降低 40%（RR = 0.6，95% CI：0.3–0.98）。未观察到母亲妊娠晚期血浆 PUFA 亚型浓度与 ASD 风险之间存在显着关联。然而，较高的血浆二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 浓度与较低的非 TD 风险相关（RR 范围为 0.93-0.99）。这项研究提供了关于母亲怀孕期间 omega3 摄入量与儿童 ASD 风险之间关系的提示性证据，但与妊娠晚期血浆 PUFA 无关。需要进一步的研究来评估这些潜在的关系。先前的研究表明，母亲在怀孕期间摄入多不饱和脂肪酸（PUFA）可能对孩子的自闭症谱系障碍（ASD）有保护作用。然而，他们没有通过怀孕期间的详细时间以及评估血浆样本中的水平来检查母亲多不饱和脂肪酸的摄入量。本研究通过问卷和生物标志物评估，调查了在规定的妊娠时间段内母亲摄入的多不饱和脂肪酸是否与儿童自闭症谱系障碍和其他非典型发育（非 TD）的风险相关。食物频率调查问卷用于估计母亲在怀孕前半程和后半程的多不饱和脂肪酸摄入量。气相色谱法测量妊娠晚期母体血浆 PUFA 浓度。来自前瞻性队列的 258 对母子被纳入其中。母亲是指已经生有患有自闭症谱系障碍 (ASD) 孩子并计划怀孕或怀上另一个孩子的母亲。对儿童进行纵向临床评估并在 36 个月时诊断。对于PUFA摄入量的问卷调查，我们只发现在怀孕后半期摄入更多omega3的母亲生出患有自闭症谱系障碍（ASD）的孩子的可能性降低了40%。对于妊娠晚期血浆中的 PUFA 浓度，我们没有观察到与 ASD 风险相关的任何统计显着性。然而，我们的研究证实了先前研究中妊娠晚期母体二十二碳六烯酸 (DHA) 和二十碳五烯酸 (EPA) 血浆浓度升高与非 TD 风险降低之间的关联。这项研究显着加深了对母亲多不饱和脂肪酸摄入量是否以及何时影响自闭症谱系障碍风险的理解，并为行为和教育层面的预防奠定了基础。
Prior research suggest that maternal polyunsaturated fatty acids (PUFAs) could have protective effects on neurodevelopmental outcomes. To examine associations between maternal PUFA intake during pregnancy and risk for autism spectrum disorder (ASD) and other non-typical development (Non-TD) in a prospective cohort. Eligible women already had a child with ASD and were planning a pregnancy or were pregnant with another child. Children were clinically assessed longitudinally and diagnosed at 36 months. Maternal PUFA intake during pregnancy was estimated using food frequency questionnaires. Maternal third-trimester plasma PUFA concentration was measured by Gas Chromatography. 258 mother-child pairs were included. Mothers consuming more total omega3 in the 2nd half of pregnancy were 40% less likely to have children with ASD (RR = 0.6, 95% CI: 0.3–0.98). No significant associations were observed between maternal third-trimester plasma PUFA subtype concentrations and risk of ASD. However, higher plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) concentrations were associated with lower Non-TD risk (RR ranging from 0.93–0.99). This study provides suggestive evidence on associations between maternal omega3 intake during pregnancy and risk of ASD in the children but not with third-trimester plasma PUFAs. Further research is needed to evaluate these potential relationships. Prior studies suggest that maternal polyunsaturated fatty acids (PUFAs) intake during pregnancy may have protective effects on autism spectrum disorder (ASD) in their children. However, they did not examine maternal PUFA intake by detailed timing during pregnancy as well as via evaluating levels in plasma samples. This study investigates whether maternal PUFAs in defined time windows of pregnancy, assessed by both questionnaires and biomarkers, are associated with risk of ASD and other non-typical development (Non-TD) in the children. Food frequency questionnaires were used to estimate maternal PUFA intake during the first and second half of pregnancy. Gas Chromatography measured maternal plasma PUFA concentrations in the third-trimester. 258 mother-child pairs from a prospective cohort were included. Mothers were those who already had a child with ASD and were planning a pregnancy or pregnant with another child. Children were clinically assessed longitudinally and diagnosed at 36 months. For PUFA intake from questionnaires, we only found mothers consuming more omega3 in the second half of pregnancy were 40% less likely to have children with ASD. For PUFA concentrations in the third-trimester plasma, we did not observe any statistical significance in relation to the risk of ASD. However, our study confirmed associations from previous studies between higher maternal docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) plasma concentrations in the late pregnancy and reduced risk for Non-TD. This study markedly advanced understandings of whether and when maternal PUFA intake influence risk for ASD and set the stage for prevention at the behavioral and educational level.
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DOI：
10.1016/j.jaac.2014.09.015
发表时间：
2014-12-01
影响因子：
13.3
作者：
Chawarska, Katarzyna;Shic, Frederick;Bryson, Susan
通讯作者：
Bryson, Susan
影响因子：
2.9
作者：
Innis, SM
通讯作者：
Innis, SM
影响因子：
2.5
作者：
Innis, Sheila M.
通讯作者：
Innis, Sheila M.
DOI：
10.1016/j.plefa.2014.12.002
发表时间：
2015-04-01
影响因子：
3
作者：
Jimenez, E. Yakes;Mangani, C.;Dewey, K. G.
通讯作者：
Dewey, K. G.
影响因子：
--
作者：
Hallmayer, Joachim;Cleveland, Sue;Torres, Andrea;Phillips, Jennifer;Cohen, Brianne;Torigoe, Tiffany;Miller, Janet;Fedele, Angie;Collins, Jack;Smith, Karen;Lotspeich, Linda;Croen, Lisa A.;Ozonoff, Sally;Lajonchere, Clara;Grether, Judith K.;Risch, Neil
通讯作者：
Risch, Neil