Nationwide surveillance in uterine cancer: survival analysis and the importance of birth cohort: 30-year population-based registry in Taiwan.
Nationwide surveillance in uterine cancer: survival analysis and the importance of birth cohort: 30-year population-based registry in Taiwan.
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DOI：
10.1371/journal.pone.0051372
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Cheng WF
中科院分区：
文献类型：
--
作者：
Huang CY;Chen CA;Chen YL;Chiang CJ;Hsu TH;Lin MC;Lai MS;Chen CJ;You SL;Cheng WF
子宫癌是台湾增长最快的恶性肿瘤，也是第二常见的妇科恶性肿瘤。我们分析了子宫癌发病率的长期趋势，并比较了台湾患有子宫癌和子宫肉瘤的女性的生存率。 1979 年至 2008 年间诊断患有子宫癌的女性数据来自台湾癌症登记处。使用Kaplan-Meier 和Cox 比例风险回归方法分析生存数据。对 11,558 名患有子宫癌的女性和 1,226 名患有子宫肉瘤的女性的记录进行了分析。子宫内膜样腺癌的年龄调整发病率从1979年至1983年的每年每10万名女性0.83人增加到2004年至2008年的每年每10万名女性7.50人。子宫内膜样腺癌女性的5年生存率（83.2%）高于透明细胞癌女性（58.3%）、浆液性癌（54.4%）和 癌肉瘤 (35.2%)（p<0.0001，对数秩检验）。患有低度恶性子宫内膜间质肉瘤、子宫内膜间质肉瘤、平滑肌肉瘤（LMS）和腺肉瘤的妇女的 5 年生存率分别为 97.5%、73.5%、60.1% 和 77.2%（p<0.0001，对数秩检验）。多因素分析显示，子宫内膜样腺癌的组织学类型、年轻年龄和2000年以后的治疗时间是女性子宫癌的独立、有利的预后因素。通过多变量分析，LMS的组织学类型、高龄和2000年以后的治疗时间是女性子宫肉瘤的独立不良预后因素。这项为期 30 年的全国性人口研究发现，子宫内膜样腺癌患者的数量随着时间的推移而增加。组织学类型、年龄和治疗周期是子宫癌的生存因素。对于这种日益常见的癌症类型，应对子宫癌和患者护理进行更全面的评估。
Uterine cancer was the most rapidly increasing malignancy and the second most common gynecologic malignancy in Taiwan. We analyzed the secular trend of uterine cancer incidence and compare the survival of women with uterine carcinomas and uterine sarcomas in Taiwan. Data on women diagnosed with uterine cancer between 1979 and 2008 were obtained from the Taiwan cancer registry. Survival data were analyzed by using Kaplan-Meier and Cox proportional hazards regression methods. Records of 11,558 women with uterine carcinomas and 1,226 women with uterine sarcomas were analyzed. The age-adjusted incidence rate of endometrioid adenocarcinoma increased from 0.83 per 100,000 women per year between 1979 and 1983 to 7.50 per 100,000 women per year between 2004 and 2008. The 5-year survival rate of women with endometrioid adenocarcinoma (83.2%) was higher than that for women with clear cell carcinoma (58.3%), serous carcinoma (54.4%), and carcinosarcoma (35.2%) (p<0.0001, log-rank test). The 5-year survival rates of women with low grade endometrial stromal sarcoma, endometrial stromal sarcoma, leiomyosarcoma (LMS), and adenosarcoma were 97.5%, 73.5%, 60.1%, and 77.2%, respectively (p<0.0001, log rank test). The histologic type of endometrioid adenocarcinoma, young age, and treatment period after 2000 were independent, favorable prognostic factors in women with uterine carcinomas by multivariate analysis. The histologic type of LMS, old age, and treatment period after 2000 were independent, poor prognostic factors in women with uterine sarcomas by multivariate analysis. An increase over time in the number of patients with endometrioid adenocarcinomas was noted in this 30-year, nationwide, population-based study. Histologic type, age and treatment period were survival factors for uterine cancers. A more comprehensive assessment of uterine cancers and patient care should be undertaken on this increasingly common type of cancer.
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DOI：
10.1046/j.1525-1438.2002.01151.x
发表时间：
2002-11-01
影响因子：
4.8
作者：
McCluggage, WG
通讯作者：
McCluggage, WG
影响因子：
2.3
作者：
Lee, MM;Chang, IYH;Huang, A
通讯作者：
Huang, A
影响因子：
4.7
作者：
KILGORE, LC;PARTRIDGE, EE;CONNER, W
通讯作者：
CONNER, W
影响因子：
5.6
作者：
HENDRICKSON, M;ROSS, J;KEMPSON, R
通讯作者：
KEMPSON, R
影响因子：
45.3
作者：
Chan, John K.;Sherman, Alexander E.;Deshmukh, Harshal
通讯作者：
Deshmukh, Harshal