Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.
Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.
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DOI：
10.3390/ijms19020476
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发表时间：
2018-02-06
影响因子：
5.6
通讯作者：
Fujitani Y
中科院分区：
文献类型：
--
作者：
Fukunaka A;Fujitani Y
缺锌是肥胖和糖尿病的危险因素。然而，直到最近，其潜在的分子机制仍不清楚。锌转运蛋白SLC30A8/ZnT8的常见多态可能增加2型糖尿病的易感性，这一突破性发现为锌在糖尿病中的作用提供了新的见解。我们等人的研究表明，锌锌转运蛋白8功能的改变可能参与了2型糖尿病的发病机制，这表明精确控制锌的稳态对于保持健康和预防各种疾病至关重要，包括与生活方式相关的疾病。最近，锌转运蛋白ZIP13在米色脂肪细胞生物发生调控中的作用被阐明，这表明锌稳态调节可能成为肥胖和代谢综合征的治疗靶点。本文综述了锌稳态在糖尿病病理生理中作用的研究进展，并提出锌分布不足可能通过调节各种重要的生物学事件而影响糖尿病和代谢性疾病的发生。
Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the underlying molecular mechanisms remained unclear. The breakthrough discovery that the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes. Our group and others showed that altered ZnT8 function may be involved in the pathogenesis of type 2 diabetes, indicating that the precise control of zinc homeostasis is crucial for maintaining health and preventing various diseases, including lifestyle-associated diseases. Recently, the role of the zinc transporter ZIP13 in the regulation of beige adipocyte biogenesis was clarified, which indicated zinc homeostasis regulation as a possible therapeutic target for obesity and metabolic syndrome. Here we review advances in the role of zinc homeostasis in the pathophysiology of diabetes, and propose that inadequate zinc distribution may affect the onset of diabetes and metabolic diseases by regulating various critical biological events.
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影响因子：
30.8
作者：
Flannick, Jason;Thorleifsson, Gudmar;Beer, Nicola L.;Jacobs, Suzanne B. R.;Grarup, Niels;Burtt, Noel P.;Mahajan, Anubha;Fuchsberger, Christian;Atzmon, Gil;Benediktsson, Rafn;Blangero, John;Bowden, Don W.;Brandslund, Ivan;Brosnan, Julia;Burslem, Frank;Chambers, John;Cho, Yoon Shin;Christensen, Cramer;Douglas, Desiree A.;Duggirala, Ravindranath;Dymek, Zachary;Farjoun, Yossi;Fennell, Timothy;Fontanillas, Pierre;Forsen, Tom;Gabriel, Stacey;Glaser, Benjamin;Gudbjartsson, Daniel F.;Hanis, Craig;Hansen, Torben;Hreidarsson, Astradur B.;Hveem, Kristian;Ingelsson, Erik;Isomaa, Bo;Johansson, Stefan;Jorgensen, Torben;Jorgensen, Marit Eika;Kathiresan, Sekar;Kong, Augustine;Kooner, Jaspal;Kravic, Jasmina;Laakso, Markku;Lee, Jong-Young;Lind, Lars;Lindgren, Cecilia M.;Linneberg, Allan;Masson, Gisli;Meitinger, Thomas;Mohlke, Karen L.;Molven, Anders;Morris, Andrew P.;Potluri, Shobha;Rauramaa, Rainer;Ribel-Madsen, Rasmus;Richard, Ann-Marie;Rolph, Tim;Salomaa, Veikko;Segre, Ayellet V.;Skaerstrand, Hanna;Steinthorsdottir, Valgerdur;Stringham, Heather M.;Sulem, Patrick;Tai, E. Shyong;Teo, Yik Ying;Teslovich, Tanya;Thorsteinsdottir, Unnur;Trimmer, Jeff K.;Tuomi, Tiinamaija;Tuomilehto, Jaakko;Vaziri-Sani, Fariba;Voight, Benjamin F.;Wilson, James G.;Boehnke, Michael;McCarthy, Mark I.;Njolstad, Pal R.;Pedersen, Oluf;Groop, Leif;Cox, David R.;Stefansson, Kari;Altshuler, David
通讯作者：
Altshuler, David
DOI：
10.1097/med.0b013e328337a81f
发表时间：
2010-04
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Cypess AM;Kahn CR
通讯作者：
Kahn CR
影响因子：
--
作者：
Hou, June Chunqiu;Min, Le;Pessin, Jeffrey E.
通讯作者：
Pessin, Jeffrey E.
影响因子：
7.7
作者：
Donath, MY;Ehses, JA;Reinecke, M
通讯作者：
Reinecke, M
影响因子：
6.8
作者：
Dodson, G;Steiner, D
通讯作者：
Steiner, D