Antimicrobial Photodynamic Inactivation Using Topical and Superhydrophobic Sensitizer Techniques: A Perspective from Diffusion in Biofilms.

Antimicrobial Photodynamic Inactivation Using Topical and Superhydrophobic Sensitizer Techniques: A Perspective from Diffusion in Biofilms.
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DOI:
10.1111/php.13461
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发表时间:
2021-11
影响因子:
3.3
通讯作者:
Greer, Alexander
Greer, Alexander
中科院分区:
生物学3区
文献类型:
--
作者:
Tonon, Caroline Coradi;Ashraf, Shoaib;Alburquerque, Jose Quilez;de Souza Rastelli, Alessandra Nara;Hasan, Tayyaba;Lyons, Alan M.;Greer, Alexander

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This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH-aPDI). This review should be of interest to photochemists, photobiologists, and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH-aPDI.
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