Serum matrix metalloproteinase 9 (MMP9) as a biochemical marker for wasting marmoset syndrome
Serum matrix metalloproteinase 9 (MMP9) as a biochemical marker for wasting marmoset syndrome
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血清基质金属蛋白酶 9 (MMP9) 作为消瘦狨猴综合征的生化标志物
DOI：
--
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发表时间：
2016
影响因子：
1.2
通讯作者：
Eiki Takahashi
中科院分区：
文献类型：
--
作者：
T. Yoshimoto;K. Niimi;Eiki Takahashi
近年来，常见的绒猴(Callithrix Jacchus)作为非人类灵长类实验动物的使用有所增加。虽然耗竭绒猴综合征(WMS)是圈养绒猴群体中最大的问题之一，但其分子机制、用于准确诊断和可靠治疗的生化标记物仍不清楚。在本研究中，作为寻找准确诊断WMS的生化标志物(S)的第一步，我们检测了血细胞计数，包括红细胞压积、血红蛋白和血小板，并检测了血清化学指标，包括白蛋白、钙和血清基质金属蛋白酶9(MMP9)水平，其中包括体重下降和非体重下降的绒猴群体。MMP9被认为是一种负责降解细胞外基质成分的酶，并参与炎症性疾病的发病机制，如人类和小鼠炎症性肠病，这些疾病与WMS一样，在组织学上以肠道中的炎性细胞浸润为特征。西药组红细胞压积、血红蛋白、血清白蛋白、血钙水平较对照组明显降低。WMS组的血小板值和血清MMP9浓度较对照组明显升高。MMP9可作为除红细胞压积、血红蛋白、血清白蛋白、钙以外诊断WMS的一项新的有用指标。我们的结果还表明，MMP9可能是一种有用的治疗分子候选。
Use of the common marmoset (Callithrix jacchus) as a non-human primate experimental animal has increased in recent years. Although wasting marmoset syndrome (WMS) is one of the biggest problems in captive marmoset colonies, the molecular mechanisms, biochemical markers for accurate diagnosis and a reliable treatment remain unknown. In this study, as a first step to finding biochemical marker(s) for the accurate diagnosis of WMS, we conducted blood cell counts, including hematocrit, hemoglobin and platelets, and examined serum chemistry values, including albumin, calcium and levels of serum matrix metalloproteinase 9 (MMP9), using a colony of marmosets with and without weight loss. MMP9 is thought to be an enzyme responsible for the degradation of extracellular matrix components and participates in the pathogenesis of inflammatory conditions, such as human and murine inflammatory bowel disease, which, like WMS, are characterized histologically by inflammatory cell infiltrations in the intestines. The values of hematocrit and hemoglobin and levels of serum albumin and calcium in the WMS group were significantly decreased versus the control group. The platelet values and serum MMP9 concentrations were increased significantly in the WMS group compared with the control group. MMP9 could be a new and useful marker for the diagnosis of WMS in addition to hematocrit, hemoglobin, serum albumin and calcium. Our results also indicate that MMP9 could be a useful molecular candidate for treatment.
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DOI：
10.1016/s0021-9258(17)46745-7
发表时间：
1993-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Lyons Jg;B. Birkedal‐Hansen;Pierson Mc;J. Whitelock;H. Birkedal-Hansen
通讯作者：
Lyons Jg;B. Birkedal‐Hansen;Pierson Mc;J. Whitelock;H. Birkedal-Hansen
影响因子：
0.8
作者：
D. Abbott;D. K. Barnett;R. Colman;M. E. Yamamoto;N. Schultz-Darken
通讯作者：
D. Abbott;D. K. Barnett;R. Colman;M. E. Yamamoto;N. Schultz-Darken
影响因子：
0.8
作者：
K. Mansfield
通讯作者：
K. Mansfield
影响因子：
30.5
作者：
Gerlach, Katharina;Hwang, YouYi;Neurath, Markus F.
通讯作者：
Neurath, Markus F.
普通狨猴（Callithrix jacchus）的临床护理和疾病。
DOI：
--
发表时间：
2003
期刊：
Comparative medicine.
影响因子：
--
作者：
Ludlage,Elisabeth;Mansfield,Keith
通讯作者：
Mansfield,Keith