lncRNome: a comprehensive knowledgebase of human long noncoding RNAs.

lncRNome: a comprehensive knowledgebase of human long noncoding RNAs.
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DOI:
10.1093/database/bat034
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发表时间:
2013
期刊:
Database : the journal of biological databases and curation
影响因子:
--
通讯作者:
Scaria V
Scaria V
中科院分区:
其他
文献类型:
--
作者:
Bhartiya D;Pal K;Ghosh S;Kapoor S;Jalali S;Panwar B;Jain S;Sati S;Sengupta S;Sachidanandan C;Raghava GP;Sivasubbu S;Scaria V

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高通量基因组规模技术的出现使我们能够解开大量以前未知的基因组转录活性区域。最近的全基因组研究提供了大量的各类非编码转录本的注释。长链非编码RNA(lncRNA)构成了这些新的注释非编码转录本的主要部分,目前已知参与了许多功能不同的生物过程。目前有超过18000种转录本被注释为lncRNA,包括以前注释的非编码转录本,包括大的基因间非编码RNA,反义RNA和加工假基因。提供稳定注释、交叉引用和生物相关信息的资源存在显着差距。lncRNome的设想是通过将各种生物学重要信息的注释整合到综合知识库中来填补这一空白。据我们所知,lncRNome是lncRNA最大和最全面的资源之一。数据库URL:http://genome.igib.res.in/lncRNome
The advent of high-throughput genome scale technologies has enabled us to unravel a large amount of the previously unknown transcriptionally active regions of the genome. Recent genome-wide studies have provided annotations of a large repertoire of various classes of noncoding transcripts. Long noncoding RNAs (lncRNAs) form a major proportion of these novel annotated noncoding transcripts, and presently known to be involved in a number of functionally distinct biological processes. Over 18 000 transcripts are presently annotated as lncRNA, and encompass previously annotated classes of noncoding transcripts including large intergenic noncoding RNA, antisense RNA and processed pseudogenes. There is a significant gap in the resources providing a stable annotation, cross-referencing and biologically relevant information. lncRNome has been envisioned with the aim of filling this gap by integrating annotations on a wide variety of biologically significant information into a comprehensive knowledgebase. To the best of our knowledge, lncRNome is one of the largest and most comprehensive resources for lncRNAs. Database URL: http://genome.igib.res.in/lncRNome
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