Optical rheology of porcine sclera by birefringence imaging.
Optical rheology of porcine sclera by birefringence imaging.
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DOI：
10.1371/journal.pone.0044026
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yasuno Y
中科院分区：
文献类型：
--
作者：
Yamanari M;Ishii K;Fukuda S;Lim Y;Duan L;Makita S;Miura M;Oshika T;Yasuno Y
利用偏振敏感光学相干断层扫描（PS-OCT）研究离体猪巩膜的双折射与弹性之间的关系。本文测量了19只猪眼的弹性参数和双折射率。在每只猪眼的颞侧，从视乳头处解剖出4条与利姆布斯平行的巩膜条，宽度为4 mm。用PS-OCT测量巩膜的双折射，用单轴材料试验机测量预处理后巩膜以1.8mm/min的速度拉伸时的应变和力。提取在0%应变下的指数拟合的应力-应变曲线的导数作为切线模量。从拟合中提取了指数应力-应变函数的幂函数。为了考虑巩膜的净刚度，将结构刚度计算为切线模量和厚度的乘积。双折射和这些弹性参数之间的相关性进行了研究。在2个中心位置，双折射率和所有的弹性参数之间存在统计学上显著的相关性。结构刚度和指数应力应变函数的功率与双折射在视乳头附近的位置。在赤道附近没有发现相关性。首次证实了巩膜的双折射率与弹性之间的相关性。本研究为利用PS-OCT进行巩膜生物力学的活体测量奠定了基础。
To investigate a relationship between birefringence and elasticity of porcine sclera ex vivo using polarization-sensitive optical coherence tomography (PS-OCT). Elastic parameters and birefringence of 19 porcine eyes were measured. Four pieces of scleral strips which were parallel to the limbus, with a width of 4 mm, were dissected from the optic nerve head to the temporal side of each porcine eye. Birefringence of the sclera was measured with a prototype PS-OCT. The strain and force were measured with a uniaxial material tester as the sample was stretched with a speed of 1.8 mm/min after preconditioning. A derivative of the exponentially-fitted stress-strain curve at 0% strain was extracted as the tangent modulus. Power of exponential stress-strain function was also extracted from the fitting. To consider a net stiffness of sclera, structural stiffness was calculated as a product of tangent modulus and thickness. Correlations between birefringence and these elastic parameters were examined. Statistically significant correlations between birefringence and all of the elastic parameters were found at 2 central positions. Structural stiffness and power of exponential stress-strain function were correlated with birefringence at the position near the optic nerve head. No correlation was found at the position near the equator. The evidence of correlations between birefringence and elasticity of sclera tested uniaxially was shown for the first time. This work may become a basis for in vivo measurement of scleral biomechanics using PS-OCT.
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影响因子：
4.4
作者：
Litwiller, Daniel V.;Lee, Sung J.;Kolipaka, Arunark;Mariappan, Yogesh K.;Glaser, Kevin J.;Pulido, Jose S.;Ehman, Richard L.
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作者：
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Hitzenberger CK
影响因子：
6.9
作者：
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通讯作者：
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影响因子：
7.7
作者：
Bouma, Brett E.;Yun, Seok-Hyun;Vakoc, Benjamin J.;Suter, Melissa J.;Tearney, Guillermo J.
通讯作者：
Tearney, Guillermo J.