MR elastography of the ex vivo bovine globe.
MR elastography of the ex vivo bovine globe.
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DOI：
10.1002/jmri.22217
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发表时间：
2010-07
影响因子：
4.4
通讯作者：
Ehman, Richard L.
中科院分区：
文献类型：
--
作者：
Litwiller, Daniel V.;Lee, Sung J.;Kolipaka, Arunark;Mariappan, Yogesh K.;Glaser, Kevin J.;Pulido, Jose S.;Ehman, Richard L.
评价磁共振弹性成像（MRE）评估眼力学特性的可行性。使用MRE和有限元建模（FEM）估计了完整的、去核的牛地球仪样本的角巩膜壳的弹性特性，假设线性、各向同性行为。二维（2D），轴对称模型的几何形状是从一个分割的2D MR图像，并在角膜和巩膜的杨氏模量的估计，在各种眼内压使用迭代弯曲波速度匹配算法。角膜和巩膜的杨氏模量的估计值分别为40至185 kPa和1至7 MPa，在眼内压范围为0.85至9.05 mmHg（1.2至12.3 cm H2O）。它们还作为波速和眼内dP/dV（“眼刚性”的经验测量）两者的函数呈指数变化。这些结果表明，它是可能的，以估计在离体牛地球仪的角巩膜壳的固有弹性特性，这表明MRE可能提供一个有用的手段来评估眼睛的机械性能和解剖结构。该技术和建模过程的进一步发展将增强其潜力，需要进一步研究以确定其临床潜力。
To evaluate the feasibility of using magnetic resonance elastography (MRE) to assess the mechanical properties of the eye. The elastic properties of the corneoscleral shell of an intact, enucleated bovine globe specimen were estimated using MRE and finite element modeling (FEM), assuming linear, isotropic behavior. The two-dimensional (2D), axisymetric model geometry was derived from a segmented 2D MR image, and estimations of the Young’s modulus in both the cornea and sclera were made at various intraocular pressures using an iterative flexural wave speed matching algorithm. Estimated values of the Young’s moduli of the cornea and sclera varied from 40 to 185 kPa and 1 to 7 MPa, respectively, over an intraocular pressure range of 0.85 to 9.05 mmHg (1.2 to 12.3 cmH2O). They also varied exponentially as functions of both wave speed and intraocular dP/dV, an empirical measure of “ocular rigidity”. These results show that it is possible to estimate the intrinsic elastic properties of the corneoscleral shell in an ex vivo bovine globe, suggesting that MRE may provide a useful means to assess the mechanical properties of the eye and its anatomy. Further development of the technique and modeling process will enhance its potential, and further investigations are needed to determine its clinical potential.
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影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL
影响因子：
2.4
作者：
Boyce, B. L.;Jones, R. E.;Grazier, J. M.
通讯作者：
Grazier, J. M.
影响因子：
3.5
作者：
Fernández, DC;Niazy, AM;Juhasz, T
通讯作者：
Juhasz, T
影响因子：
3.4
作者：
BRUBAKER, RF;EZEKIEL, S;BEELER, GW
通讯作者：
BEELER, GW
影响因子：
4.4
作者：
Pallikaris, IG;Kymionis, GD;Tsilimbaris, MK
通讯作者：
Tsilimbaris, MK