Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes.

Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes.
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DOI:
10.1016/j.ejrad.2009.01.045
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发表时间:
2009-05
影响因子:
3.3
通讯作者:
Wang LV
Wang LV
中科院分区:
医学3区
文献类型:
--
作者:
Song KH;Kim C;Maslov K;Wang LV

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Sentinel lymph node (SLN) biopsy has increasingly become important in axillary staging of breast cancer patients since SLN biopsy alleviates the postoperative complications of previously practiced axillary lymph node dissections. Nevertheless, the procedures of SLN biopsy using blue dye and radioactive substance are still intraoperative, and the latter methods are also ionizing. In this pilot study, we have proposed noninvasive in vivo spectroscopic photoacoustic (PA) SLN mapping using gold nanorods as lymph node tracers in a rat model. Gold nanorods have biocompatibility, high optical absorption, and easily tuned surface plasmon resonance peak wavelength.
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