The functional anatomy of schizophrenia: A dynamic causal modeling study of predictive coding.
The functional anatomy of schizophrenia: A dynamic causal modeling study of predictive coding.
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DOI：
10.1016/j.schres.2014.06.011
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发表时间：
2014-09
影响因子：
4.5
通讯作者：
Friston, Karl
中科院分区：
文献类型：
--
作者：
Fogelson, Noa;Litvak, Vladimir;Peled, Avi;Fernandez-del-Olmo, Miguel;Friston, Karl
本文测试的假设，精神分裂症患者有缺陷的选择性参加可预测的事件。我们使用动态因果模型（DCM）的电生理反应-可预测的和不可预测的视觉目标-量化的有效连接内和之间的皮质来源的视觉层次在25名精神分裂症患者和25名年龄匹配的控制。我们发现，在视觉系统中，从高层次到低层次的外在后向连接的强度在正常受试者和精神分裂症患者之间存在显著差异。此外，我们发现，精神分裂症受试者不仅有异常的连接，而且他们未能调整或优化这种连接时，事件可以预测。因此，与对照组相比，精神分裂症患者在处理可预测与不可预测的目标时观察到的差异性内在递归连接明显减弱，这表明未能调节负责将预测错误的感觉信息传递到视觉皮层层次的神经元的敏感性。这些发现支持了异常连接在精神分裂症的神经病理学和病理生理学中的作用。
This paper tests the hypothesis that patients with schizophrenia have a deficit in selectively attending to predictable events. We used dynamic causal modeling (DCM) of electrophysiological responses – to predictable and unpredictable visual targets – to quantify the effective connectivity within and between cortical sources in the visual hierarchy in 25 schizophrenia patients and 25 age-matched controls. We found evidence for marked differences between normal subjects and schizophrenia patients in the strength of extrinsic backward connections from higher hierarchical levels to lower levels within the visual system. In addition, we show that not only do schizophrenia subjects have abnormal connectivity but also that they fail to adjust or optimize this connectivity when events can be predicted. Thus, the differential intrinsic recurrent connectivity observed during processing of predictable versus unpredictable targets was markedly attenuated in schizophrenia patients compared with controls, suggesting a failure to modulate the sensitivity of neurons responsible for passing sensory information of prediction errors up the visual cortical hierarchy. The findings support the proposed role of abnormal connectivity in the neuropathology and pathophysiology of schizophrenia.
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影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
影响因子：
2.9
作者：
Feldman H;Friston KJ
通讯作者：
Friston KJ
DOI：
10.1098/rstb.2005.1622
发表时间：
2005-04-29
影响因子：
6.3
作者：
Friston, KJ
通讯作者：
Friston, KJ
影响因子：
5.4
作者：
COHEN, JD;SERVANSCHREIBER, D
通讯作者：
SERVANSCHREIBER, D
影响因子：
5.7
作者：
Litvak V;Jha A;Flandin G;Friston K
通讯作者：
Friston K