Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial.
Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial.
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巴西坚果摄入可改善肥胖青少年的脂质谱，氧化应激和微血管功能：一项随机对照试验。
DOI：
10.1186/1743-7075-8-32
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发表时间：
2011-05-28
影响因子：
4.5
通讯作者：
Bouskela E
中科院分区：
文献类型：
--
作者：
Maranhão PA;Kraemer-Aguiar LG;de Oliveira CL;Kuschnir MC;Vieira YR;Souza MG;Koury JC;Bouskela E
Obesity is a chronic disease associated to an inflammatory process resulting in oxidative stress that leads to morpho-functional microvascular damage that could be improved by some dietary interventions. In this study, the intake of Brazil nuts (Bertholletia excelsa), composed of bioactive substances like selenium, α- e γ- tocopherol, folate and polyunsaturated fatty acids, have been investigated on antioxidant capacity, lipid and metabolic profiles and nutritive skin microcirculation in obese adolescents. Obese female adolescents (n = 17), 15.4 ± 2.0 years and BMI of 35.6 ± 3.3 kg/m2, were randomized 1:1 in two groups with the diet supplemented either with Brazil nuts [BNG, n = 08, 15-25 g/day (equivalent to 3 to 5 units/day)] or placebo [PG (lactose), n = 09, one capsule/day] and followed for 16 weeks. Anthropometry, metabolic-lipid profiles, oxidative stress and morphological (capillary diameters) and functional [functional capillary density, red blood cell velocity (RBCV) at baseline and peak (RBCVmax) and time (TRBCVmax) to reach it during post-occlusive reactive hyperemia, after 1 min arterial occlusion] microvascular variables were assessed by nailfold videocapillaroscopy at baseline (T0) and after intervention (T1). T0 characteristics were similar between groups. At T1, BNG (intra-group variation) had increased selenium levels (p = 0.02), RBCV (p = 0.03) and RBCVmax (p = 0.03) and reduced total (TC) (p = 0.02) and LDL-cholesterol (p = 0.02). Compared to PG, Brazil nuts intake reduced TC (p = 0.003), triglycerides (p = 0.05) and LDL-ox (p = 0.02) and increased RBCV (p = 0.03). Brazil nuts intake improved the lipid profile and microvascular function in obese adolescents, possibly due to its high level of unsaturated fatty acids and bioactive substances. Clinical Trials.gov NCT00937599
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影响因子：
3.1
作者：
de Jongh, Renate T.;Serne, Erik H.;Stehouwer, Coen D. A.
通讯作者：
Stehouwer, Coen D. A.
影响因子：
3.1
作者：
Kraemer-Aguiar, Luiz G.;Maranhao, Priscila A.;Bouskela, Eliete
通讯作者：
Bouskela, Eliete
影响因子：
7.1
作者：
Rajaram, Sujatha;Haddad, Ella Hasso;Sabate, Joan
通讯作者：
Sabate, Joan
DOI：
10.1515/bmte.1997.42.6.168
发表时间：
1997-06-01
期刊：
BIOMEDIZINISCHE TECHNIK
影响因子：
--
作者：
Klyscz, T;Junger, M;Zeintl, H
通讯作者：
Zeintl, H
影响因子：
3.1
作者：
MEININGER, GA
通讯作者：
MEININGER, GA