Effect of depression before breast cancer diagnosis on mortality among postmenopausal women.
Effect of depression before breast cancer diagnosis on mortality among postmenopausal women.
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作者：
Liang X;Margolis KL;Hendryx M;Reeves K;Wassertheil-Smoller S;Weitlauf J;Danhauer SC;Chlebowski RT;Caan B;Qi L;Lane D;Lavasani S;Luo J
在诊断乳腺癌之前患有新发抑郁症的女性，如果在晚期诊断，其全因死亡和乳腺癌死亡的风险会适度但显着增加。研究结果还强调了预防工作对于支持心理健康和预防老年妇女首次出现抑郁症的重要性。之前很少有研究调查乳腺癌诊断前的抑郁症和乳腺癌特定死亡率，并检查在多个时间点测量的抑郁症。本研究旨在调查在乳腺癌诊断前两个时间点测量的抑郁症（单独抑郁症状和使用抗抑郁药物相结合）对老年绝经后妇女的全因死亡率和乳腺癌特异性死亡率的影响。使用了一个大型前瞻性队列，即妇女健康倡议（WHI）。该研究纳入了 3095 名患有乳腺癌的女性，她们在诊断前、基线和第三年测量了抑郁症状和抗抑郁药物的使用情况。使用多变量 Cox 比例风险回归来估计基线抑郁症、第三年抑郁症以及这些时间点抑郁症组合与全因死亡率和乳腺癌特异性死亡率之间的调整后风险比。调整多个协变量后，乳腺癌诊断前第三年的抑郁症与较高的全因死亡率相关（HR，1.35；95% CI，1.02-1.78）。无论第三年是否也存在抑郁症，基线抑郁症与全因死亡率或乳腺癌特异性死亡率之间没有统计学上的显着关联。在患有晚期（区域或远处）乳腺癌的女性中，第三年新出现的抑郁症与全因死亡率（HR，2.00；95% CI，1.13-3.56）和乳腺癌特异性死亡率（HR，2.42；95% CI，1.24-4.70）显着相关。在诊断乳腺癌之前患有新发抑郁症的女性全因死亡和晚期乳腺癌死亡的风险略有增加，但显着增加。
Women with newly developed depression before the diagnosis of breast cancer had a modestly but significantly increased risk for death from any cause and death from breast cancer if diagnosed at late stage. The results also highlight the importance of prevention efforts to support mental health and prevent initial emergence of depression among older women. Few previous studies investigating depression before breast cancer diagnosis and breast cancer specific mortality have examined depression measured at more than one time point. This study aims to investigate the effect of depression (combining depressive symptoms alone and with antidepressant use) measured at two time points before breast cancer diagnosis on all-cause mortality and breast cancer-specific mortality among older postmenopausal women. A large prospective cohort, the Women's Health Initiative (WHI), was used. The study included 3095 women with incident breast cancer who had measures of depressive symptoms and antidepressant use before diagnosis at baseline and at Year three. Multivariable Cox proportional hazards regression was used to estimate adjusted hazard ratios between depression at baseline, depression at Year three, and combinations of depression at these time points, and all-cause mortality and breast cancer-specific mortality. Depression at Year three before breast cancer diagnosis was associated with higher all-cause mortality after adjusting for multiple covariates (HR, 1.35; 95% CI, 1.02-1.78). There was no statistically significant association of baseline depression and all-cause mortality or breast cancer-specific mortality, whether or not depression was also present at Year three. In women with late-stage (regional or distant stage) breast cancer newly developed depression at Year three was significantly associated with both all-cause mortality (HR, 2.00; 95% CI, 1.13-3.56) and breast cancer specific mortality (HR, 2.42; 95% CI, 1.24-4.70). Women with newly developed depression before the diagnosis of breast cancer had a modestly but significantly increased risk for death from any cause and death from breast cancer in late stage.
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妇女健康计划观察性研究的65岁及65岁妇女的抗抑郁药，抑郁症状和事件脆弱。
影响因子：
6.3
作者：
Lakey SL;LaCroix AZ;Gray SL;Borson S;Williams CD;Calhoun D;Goveas JS;Smoller JW;Ockene JK;Masaki KH;Coday M;Rosal MC;Woods NF
通讯作者：
Woods NF
影响因子：
3.6
作者：
Kanani, R.;Davies, E. A.;Jack, R. H.
通讯作者：
Jack, R. H.
影响因子：
45.3
作者：
JAMISON, RN;BURISH, TG;WALLSTON, KA
通讯作者：
WALLSTON, KA
DOI：
10.1158/1055-9965.epi-15-1063
发表时间：
2016-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Brown SB;Hankinson SE;Arcaro KF;Qian J;Reeves KW
通讯作者：
Reeves KW
DOI：
10.1111/j.1532-5415.2004.52018.x
发表时间：
2004-01-01
影响因子：
6.3
作者：
Goodwin, JS;Zhang, DD;Ostir, GV
通讯作者：
Ostir, GV