Chemerin as a Driver of Hypertension: A Consideration.
Chemerin as a Driver of Hypertension: A Consideration.
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DOI：
10.1093/ajh/hpaa084
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发表时间：
2020-11-03
影响因子：
3.2
通讯作者：
Watts SW
中科院分区：
文献类型：
--
作者：
Ferland DJ;Mullick AE;Watts SW
The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with body mass index, visceral fat, and blood pressure. Here, we focus on the specific relationship of chemerin and blood pressure with the goal of understanding whether and how chemerin drives (pathological) changes in blood pressure such that it could be interfered with therapeutically. We dissect the biosynthesis of chemerin and how current antihypertensive medications change chemerin metabolism. This is followed with a review of what is known about where chemerin is synthesized in the body and what chemerin and its receptors can do to the physiological function of organs important to blood pressure determination (e.g., brain, heart, kidneys, blood vessels, adrenal, and sympathetic nervous system). We synthesize from the literature our best understanding of the mechanisms by which chemerin modifies blood pressure, with knowledge that plasma/serum levels of chemerin may be limited in their pathological relevance. This review reveals several gaps in our knowledge of chemerin biology that could be filled by the collective work of protein chemists, biologists, pharmacologists, and clinicians.
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DOI：
10.4103/1319-2442.275482
发表时间：
2019-11-01
影响因子：
0.5
作者：
El-Khashab, Sahier Omar;Gamil, Mona;Hamed, Soha Talat
通讯作者：
Hamed, Soha Talat
影响因子：
3.8
作者：
Derosa, Giuseppe;Catena, Gabriele;Maffioli, Pamela
通讯作者：
Maffioli, Pamela
影响因子：
2
作者：
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通讯作者：
Sun, Hongzhi
影响因子：
4.6
作者：
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通讯作者：
Cantaluppi, Vincenzo
影响因子：
1.2
作者：
Dong, Baokang;Ji, Weihua;Zhang, Yanjun
通讯作者：
Zhang, Yanjun