Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task.
Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task.
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DOI：
10.1371/journal.pone.0122063
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Napier TC
中科院分区：
文献类型：
--
作者：
Tedford SE;Persons AL;Napier TC
纹状体回路中多巴胺传递失调与冲动性有关。目前的研究评估了多巴胺能输入到背外侧纹状体对冲动选择的影响，这是冲动行为的一个方面。我们实施了一项操作性任务，通过延迟折扣测量大鼠的冲动选择，其中颅内自我刺激（ICSS）被用作阳性标记。为此，将大鼠麻醉以允许在一侧半球的外侧下丘脑内植入刺激电极，并双侧背侧纹状体注射多巴胺能毒素、6-OHDA（损伤）或其载体（假手术）。恢复后，在延迟折扣任务中训练大鼠，其中它们在杠杆按压后立即呈现的小ICSS电流和按压替代杠杆后0至15秒延迟后呈现的大ICSS电流之间进行选择。任务获取和识别是相似的病变和假大鼠。所有大鼠表现出对大容量的初始偏好，并且随着延迟的增加，对大容量的偏好降低，这表明大容量的主观价值作为延迟时间的函数被打折。然而，这种折扣效应显着增强损伤大鼠的较长的延迟。这些数据揭示了多巴胺能输入的背外侧纹状体的冲动选择行为的贡献，并提供了新的见解折扣行为的神经基板。
Dysregulated dopamine transmission in striatal circuitry is associated with impulsivity. The current study evaluated the influence of dopaminergic inputs to the dorsolateral striatum on impulsive choice, one aspect of impulsive behavior. We implemented an operant task that measures impulsive choice in rats via delay discounting wherein intracranial self-stimulation (ICSS) was used as the positive reinforcer. To do so, rats were anesthetized to allow implanting of a stimulating electrode within the lateral hypothalamus of one hemisphere and bilateral dorsal striatal injections of the dopaminergic toxin, 6-OHDA (lesioned) or its vehicle (sham). Following recovery, rats were trained in a delay discounting task wherein they selected between a small ICSS current presented immediately after lever pressing, and a large ICSS current presented following a 0 to 15s delay upon pressing the alternate lever. Task acquisition and reinforcer discrimination were similar for lesioned and sham rats. All rats exhibited an initial preference for the large reinforcer, and as the delay was increased, preference for the large reinforcer was decreased indicating that the subjective value of the large reinforcer was discounted as a function of delay time. However, this discounting effect was significantly enhanced in lesioned rats for the longer delays. These data reveal a contribution of dopaminergic inputs to the dorsolateral striatum on impulsive choice behavior, and provide new insights into neural substrates underlying discounting behaviors.
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影响因子：
2.5
作者：
Gregorios-Pippas L;Tobler PN;Schultz W
通讯作者：
Schultz W
选择性多巴胺能化合物对延迟减少任务的影响。
影响因子：
1.6
作者：
Koffarnus MN;Newman AH;Grundt P;Rice KC;Woods JH
通讯作者：
Woods JH
影响因子：
13.5
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Koffarnus, Mikhail N.;Gatchalian, Kirstin M.
通讯作者：
Gatchalian, Kirstin M.
影响因子：
1.3
作者：
Alessi, SM;Petry, NM
通讯作者：
Petry, NM
影响因子：
1.3
作者：
Heilbronner, Sarah R.;Meck, Warren H.
通讯作者：
Meck, Warren H.