Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan.
Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan.
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DOI：
10.1016/j.vaccine.2015.08.048
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发表时间：
2015-11-25
期刊：
影响因子：
5.5
通讯作者：
Khuri-Bulos N
中科院分区：
文献类型：
--
作者：
Halasa N;Williams J;Faouri S;Shehabi A;Vermund SH;Wang L;Fonnesbeck C;Khuri-Bulos N
呼吸道合胞病毒（RSV）是全球婴幼儿毛细支气管炎和病毒性肺炎的主要病因。在中东和阿拉伯国家，RSV相关住院治疗的负担特征不明确。我们试图确定约旦安曼幼儿RSV住院的负担和临床/流行病学特征。我们调查了包括维生素D水平在内的严重程度的风险因素。我们对2010年3月16日至2013年3月31日在Al-Bashir政府医院因呼吸道症状和/或发热入院的2岁以下儿童进行了病毒监测，并提供了临床和人口统计学数据。获取鼻/喉拭子并置于裂解缓冲液中，并在−80 °C下冷冻，直至通过实时RT-PCR检测11种呼吸道病毒。采集足跟采血或血清样本，测定25-羟基维生素D [25（OH）D]水平，并送至中心实验室进行质谱分析。在3168名儿童中，超过80%的儿童对一种病毒检测呈阳性，RSV是最常见的病毒（44%）。与RSV相关的住院率在6个月以下的儿童中最高，每年为每1000人21.1-25.9人，而6-11个月的儿童为6.0-8.0人，12-23个月的儿童为1.6-2.5人。与RSV阴性儿童相比，RSV阳性儿童更有可能以前健康，没有潜在的医疗条件，早产的可能性较小，补充氧气的使用频率较高，维生素D水平中位数较低。RSV阳性儿童吸氧的风险因素包括基础医疗条件、缺乏母乳喂养、年龄较小和病毒载量较高。RSV是住院约旦儿童的主要病因，与其他呼吸道病毒相比，其严重程度增加。中东的RSV儿童将受益于未来的RSV疫苗和抗病毒治疗。
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children worldwide. In the Middle East and Arab countries, the burden of RSV-associated hospitalizations is not well characterized. We sought to determine the burden and clinical/epidemiological characteristics of RSV hospitalization in young children in Amman, Jordan. We investigated risk factors for severity including vitamin D levels. We conducted viral surveillance with clinical and demographic data in children <2 years admitted with respiratory symptoms and/or fever at the Al-Bashir Government Hospital from March16, 2010 to March 31, 2013. Nasal/throat swabs were obtained and placed into lysis buffer, and frozen at −80 °C until testing by real-time RT-PCR for 11 respiratory viruses. Heel stick blood or sera samples for 25-hydroxyvitamin D [25(OH)D] levels were obtained and sent to a central laboratory for mass spectrometry. Of the 3168 children, >80% testing positive for one virus, with RSV the most common virus detected (44%). The RSV-associated hospitalization rate was highest in children <6 months with an annual range of 21.1–25.9 per 1000, compared to 6.0–8.0 in 6–11-month-olds and 1.6–2.5 in 12–23-month-olds. RSV-positive children compared with RSV-negative were more likely to be previously healthy without underlying medical conditions, less likely to be born prematurely, had a higher frequency of supplemental oxygen use, and had lower median vitamin D levels. Risk factors for oxygen use in RSV-positive children included underlying medical conditions, lack of breastfeeding, younger age, and higher viral load. RSV is a major cause of illness in hospitalized Jordanian children and is associated with increased severity compared to other respiratory viruses. Children with RSV in the Middle East would benefit from future RSV vaccines and antiviral therapy.
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影响因子：
11.8
作者：
Al-Sonboli N;Hart CA;Al-Aghbari N;Al-Ansi A;Ashoor O;Cuevas LE
通讯作者：
Cuevas LE
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
4.8
作者：
Ali S;Ali I;Azam S;Ahmad B
通讯作者：
Ahmad B
影响因子：
8
作者：
Breese, Caroline;Weinberg, Geoffrey A.;Iwane, Marika K.
通讯作者：
Iwane, Marika K.
影响因子：
8
作者：
Bocchini, Joseph A., Jr.;Bernstein, Henry H.;Frantz, Jennifer
通讯作者：
Frantz, Jennifer