3 versus 7 Tesla magnetic resonance imaging for parcellations of subcortical brain structures in clinical settings.
3 versus 7 Tesla magnetic resonance imaging for parcellations of subcortical brain structures in clinical settings.
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DOI：
10.1371/journal.pone.0236208
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Alkemade A
中科院分区：
文献类型：
--
作者：
Isaacs BR;Mulder MJ;Groot JM;van Berendonk N;Lute N;Bazin PL;Forstmann BU;Alkemade A
7特斯拉(7T)磁共振成像在临床上改进人脑的可视化方面大有可为。为了评估7T在小脑结构的定位方面是否更好，我们比较了红核、丘脑底核、黑质、苍白球内侧和外侧的手法定位。这些切片是在临床上常用的各向异性临床3T上创建的，具有优化的各向同性(O)3T和标准7T扫描。临床上的3T MRI扫描由于空间分辨率有限，无法描绘出解剖上可信的结构。O3T组与7T组直接比较。我们发现，7T的表现优于o3T MRI，这反映在较高的Dice分数上，Dice分数被用来衡量定量敏感性图上手动分组的评价者之间的一致性。这种一致性的增加与较小结构的对比度与噪声比有关，但与较大的苍白球节段无关。此外，还进行了对照分析，通过评估半自动包装来说明人工包装中的潜在偏差。这些结果表明，与优化的3T相比，7T的结构体积具有更高的一致性，这说明了使用各向同性体素对手术靶区进行3D可视化的重要性。总而言之，这些结果表明，考虑到临床环境的限制，7T的表现优于C3T和o3T。
7 Tesla (7T) magnetic resonance imaging holds great promise for improved visualization of the human brain for clinical purposes. To assess whether 7T is superior regarding localization procedures of small brain structures, we compared manual parcellations of the red nucleus, subthalamic nucleus, substantia nigra, globus pallidus interna and externa. These parcellations were created on a commonly used clinical anisotropic clinical 3T with an optimized isotropic (o)3T and standard 7T scan. The clinical 3T MRI scans did not allow delineation of an anatomically plausible structure due to its limited spatial resolution. o3T and 7T parcellations were directly compared. We found that 7T outperformed the o3T MRI as reflected by higher Dice scores, which were used as a measurement of interrater agreement for manual parcellations on quantitative susceptibility maps. This increase in agreement was associated with higher contrast to noise ratios for smaller structures, but not for the larger globus pallidus segments. Additionally, control-analyses were performed to account for potential biases in manual parcellations by assessing semi-automatic parcellations. These results showed a higher consistency for structure volumes for 7T compared to optimized 3T which illustrates the importance of the use of isotropic voxels for 3D visualization of the surgical target area. Together these results indicate that 7T outperforms c3T as well as o3T given the constraints of a clinical setting.
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影响因子：
2
作者：
Hamel, Wolfgang;Koeppen, Johannes A.;Lozano, Andres M.
通讯作者：
Lozano, Andres M.
影响因子：
3.7
作者：
Isaacs, Bethany. R.;Trutti, Anne. C.;Keuken, Max. C.
通讯作者：
Keuken, Max. C.
影响因子：
19.7
作者：
Aquino, Domenico;Bizzi, Alberto;Chiapparini, Luisa
通讯作者：
Chiapparini, Luisa
影响因子：
2.7
作者：
Keuken MC;Isaacs BR;Trampel R;van der Zwaag W;Forstmann BU
通讯作者：
Forstmann BU
影响因子：
4.8
作者：
DICE, LR
通讯作者：
DICE, LR