Methodological approach for an integrated female-specific study of anxiety and smoking comorbidity.
Methodological approach for an integrated female-specific study of anxiety and smoking comorbidity.
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DOI：
10.3389/fpsyt.2023.1267753
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发表时间：
2023
影响因子：
4.7
通讯作者：
Abrantes, Ana M.
中科院分区：
文献类型：
--
作者：
Farris, Samantha G.;Smith, Jacqueline E.;Steinberg, Dana R.;Altman, Brianna R.;Lambert-Messerlian, Geralyn M.;Dunsiger, Shira I.;Williams, David M.;Saladin, Michael E.;Abrantes, Ana M.
关键词：
在女性月经周期中波动的两种主要卵巢激素雌二醇和孕酮在不同的文献中被独立地与尼古丁强化和焦虑精神病理学联系起来。我们在这些文献中确定了现有的方法学限制，描述了一个示例协议，该协议是为解决这些限制而开发的，突出了案例示例，并提供了对所产生的优势和挑战的见解。该方案是一项观察性、前瞻性、受试者内研究，对女性吸烟者进行了完整月经周期的随访。从社区招募了年龄在18-40岁之间、月经周期正常（长度为25-35天）的非寻求治疗的女性吸烟者（N = 50）。患有焦虑或情绪精神病理学的女性占样本的38.0%。每天早晨通过家庭唾液收集方法评估唾液孕酮和雌二醇。通过移动的应用程序使用生态瞬时评估（EMA）收集了焦虑和尼古丁强化的自我报告的日内瞬时评级。方案依从性> 85%。在孕酮和雌二醇、焦虑和尼古丁渴望措施中观察到受试者内和受试者间的异质性，特别是在焦虑精神病理学的背景下。本研究旨在整合焦虑和尼古丁依赖的相关文献，推进卵巢激素作用的实证研究。该协议反映了一个密集的，但可行的方法来收集日常水平的自然数据有关的雌二醇，孕酮，焦虑，尼古丁强化。
Two primary ovarian hormones that fluctuate across the female menstrual cycle—estradiol and progesterone—have been independently linked in separate literatures to nicotine reinforcement and anxiety psychopathology. We identify existing methodological limitations in these literatures, describe an example protocol that was developed to address such limitations, highlight case examples, and offer insights on the resulting advantages and challenges. This protocol was an observational, prospective, within-subjects study of female cigarette smokers who were followed over the course of a complete menstrual cycle. Non-treatment seeking, female cigarette smokers (N = 50), between the ages of 18–40 who have a normal menstrual cycle (25–35 days in length) were recruited from the community. Females with anxiety or mood psychopathology represented 38.0% of the sample. Salivary progesterone and estradiol were assessed each morning via at-home saliva collection methods. Self-reported within-day momentary ratings of anxiety and nicotine reinforcement were collected using ecological momentary assessment (EMA) via a mobile app. Protocol compliance was >85%. Within- and between-subjects heterogeneity was observed in the progesterone and estradiol, anxiety, and nicotine craving measures, especially in the context of anxiety psychopathology. We aimed to integrate the anxiety and nicotine dependence literatures and advance the empirical study of the role of ovarian hormones. This protocol reflects an intensive, yet feasible approach to collecting daily-level naturalistic data related to estradiol, progesterone, anxiety, and nicotine reinforcement.
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影响因子：
3.7
作者：
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通讯作者：
Ost, Lars-Goran
影响因子：
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通讯作者：
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DOI：
10.1016/j.pnpbp.2008.07.016
发表时间：
2008-12-12
影响因子：
5.6
作者：
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通讯作者：
Bagdy, G.
影响因子：
3.7
作者：
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通讯作者：
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