Unconventional low-cost fabrication and patterning techniques for point of care diagnostics.
Unconventional low-cost fabrication and patterning techniques for point of care diagnostics.
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DOI：
10.1007/s10439-010-0213-1
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发表时间：
2011-04
影响因子：
3.8
通讯作者：
Khine, Michelle
中科院分区：
文献类型：
--
作者：
Sharma, Himanshu;Diep Nguyen;Chen, Aaron;Lew, Valerie;Khine, Michelle
快速、定量和灵敏诊断的潜力催生了许多用于护理诊断应用的创新“芯片实验室”技术。由于这些芯片的设计必须在严格的成本限制下才能广泛部署，因此该领域的最新研究产生了极其新颖的非传统微米和纳米制造创新。这些进步也可用于其他生物测定，包括定制测定开发和学术原型设计。这里回顾的技术利用极低成本的基材和易于采用的方法，以前所未有的方式以高分辨率对结构和生物材料进行图案化。这些新方法有望以更少的资本设备投资和更大的设计灵活性实现更快速的原型设计。尽管这些技术仍处于起步阶段，但与传统方法相比，它们具有提高分辨率、灵敏度、灵活性和节省成本的潜力。
The potential of rapid, quantitative, and sensitive diagnosis has led to many innovative ‘lab on chip’ technologies for point of care diagnostic applications. Because these chips must be designed within strict cost constraints to be widely deployable, recent research in this area has produced extremely novel non-conventional micro- and nano-fabrication innovations. These advances can be leveraged for other biological assays as well, including for custom assay development and academic prototyping. The technologies reviewed here leverage extremely low-cost substrates and easily adoptable ways to pattern both structural and biological materials at high resolution in unprecedented ways. These new approaches offer the promise of more rapid prototyping with less investment in capital equipment as well as greater flexibility in design. Though still in their infancy, these technologies hold potential to improve upon the resolution, sensitivity, flexibility, and cost-savings over more traditional approaches.
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