Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment.
Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment.
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用于肿瘤治疗的刺激响应释放功能药物输送系统的最新进展
DOI：
10.3390/molecules21121715
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发表时间：
2016-12-20
期刊：
影响因子：
--
通讯作者：
Fu J
中科院分区：
文献类型：
--
作者：
Ding C;Tong L;Feng J;Fu J
得益于纳米技术的发展，具有刺激响应型控释功能的药物递送系统在临床抗肿瘤应用中显示出巨大的潜力。通过使用DDS，可以最大程度地避免传统抗癌药物治疗的严重副作用和对正常组织器官的损害。一个理想的DDS必须首先满足生物安全标准，其次是大药物有效载荷和控释功能的效率相关要求。本文综述了近年来有关具有刺激反应特性的DDSS的研究进展。第一部分简要综述了DDSS的纳米支架，包括介孔纳米颗粒、聚合物、金属有机骨架(MOF)、量子点(Qds)和碳纳米管(CNTs)。第二部分介绍了刺激响应机制的主要类型，并将其分为两类：内在机制(pH、氧化还原状态、生物分子)和外在机制(温度、光照射、磁场和超声波)。并对DDS的临床应用、未来面临的挑战和前景进行了展望。
Benefiting from the development of nanotechnology, drug delivery systems (DDSs) with stimuli-responsive controlled release function show great potential in clinical anti-tumor applications. By using a DDS, the harsh side effects of traditional anti-cancer drug treatments and damage to normal tissues and organs can be avoided to the greatest extent. An ideal DDS must firstly meet bio-safety standards and secondarily the efficiency-related demands of a large drug payload and controlled release function. This review highlights recent research progress on DDSs with stimuli-responsive characteristics. The first section briefly reviews the nanoscale scaffolds of DDSs, including mesoporous nanoparticles, polymers, metal-organic frameworks (MOFs), quantum dots (QDs) and carbon nanotubes (CNTs). The second section presents the main types of stimuli-responsive mechanisms and classifies these into two categories: intrinsic (pH, redox state, biomolecules) and extrinsic (temperature, light irradiation, magnetic field and ultrasound) ones. Clinical applications of DDS, future challenges and perspectives are also mentioned.
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影响因子：
16.1
作者：
Chacko RT;Ventura J;Zhuang J;Thayumanavan S
通讯作者：
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影响因子：
17.1
作者：
Ashley CE;Carnes EC;Epler KE;Padilla DP;Phillips GK;Castillo RE;Wilkinson DC;Wilkinson BS;Burgard CA;Kalinich RM;Townson JL;Chackerian B;Willman CL;Peabody DS;Wharton W;Brinker CJ
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影响因子：
17.1
作者：
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通讯作者：
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影响因子：
17.1
作者：
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影响因子：
4.9
作者：
Chang, Yincheng;Hou, Chenxi;Pei, Zhichao
通讯作者：
Pei, Zhichao