Biomechanics: cell research and applications for the next decade.
Biomechanics: cell research and applications for the next decade.
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DOI：
10.1007/s10439-009-9661-x
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发表时间：
2009-05
影响因子：
3.8
通讯作者：
Weinbaum, Sheldon
中科院分区：
文献类型：
--
作者：
Discher, Dennis;Dong, Cheng;Fredberg, Jeffrey J.;Guilak, Farshid;Ingber, Donald;Janmey, Paul;Kamm, Roger D.;Schmid-Schoenbein, Geert W.;Weinbaum, Sheldon
随着最近分子生物学的革命和人类基因组的破译，我们对构成生命系统的构建模块的理解迅速发展。然而，我们还没有弄清楚，赋予生命的物理力量是如何影响这些分子构件的合成、折叠、组装和功能的。我们同样不确定这些构建模块如何动态地相互作用，以创建耦合的调节网络，从而产生整合的生物行为。在这里，我们回顾了生物力学领域在细胞和分子水平上的一些最新进展，并提出了该领域面临的一些挑战。生命系统作为多分子集体工作和移动，为了了解健康和疾病的关键方面，我们必须首先能够解释物理力和机械结构如何有助于活细胞和组织的“活性”材料特性，以及这些力如何影响信息处理和细胞决策。这些见解无疑将为基础生物学和合理工程学提供有效的临床治疗新方法。
With the recent revolution in Molecular Biology and the deciphering of the Human Genome, our understanding of the building blocks that comprise living systems has advanced rapidly. We have yet to understand, however, how the physical forces that animate life affect the synthesis, folding, assembly, and function of these molecular building blocks. We are equally uncertain as to how these building blocks interact dynamically to create coupled regulatory networks from which integrative biological behaviors emerge. Here we review several recent advances in the field of biomechanics at the cellular and molecular levels, and we set forth some of the challenges confronting the field. Living systems work and move as multi-molecular collectives, and in order to understand key aspects of health and disease we must first be able to explain how physical forces and mechanical structures contribute to the ‘active’ material properties of living cells and tissues, as well as how these forces impact information processing and cellular decision making. Such insights will no doubt inform basic biology and rational engineering of effective new approaches to clinical therapy.
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DOI：
10.1115/1.1318906
发表时间：
2000-12-01
影响因子：
1.7
作者：
Butler, DL;Goldstein, SA;Guilak, F
通讯作者：
Guilak, F
影响因子：
41.2
作者：
Deng, Linhong;Trepat, Xavier;Fredberg, Jeffrey J.
通讯作者：
Fredberg, Jeffrey J.
影响因子：
19.6
作者：
De, Rumi;Zemel, Assaf;Safran, Samuel A.
通讯作者：
Safran, Samuel A.
影响因子：
3.4
作者：
Brujic, Jasna;Hermans, Rodolfo I. Z.;Fernandez, Julio M.
通讯作者：
Fernandez, Julio M.
影响因子：
4.1
作者：
Dean, Dylan M.;Morgan, Jeffrey R.
通讯作者：
Morgan, Jeffrey R.