Accelerated Long-Term Hearing Loss Progression After Recovery From Idiopathic Sudden Sensorineural Hearing Loss.
Accelerated Long-Term Hearing Loss Progression After Recovery From Idiopathic Sudden Sensorineural Hearing Loss.
复制标题
DOI：
10.3389/fneur.2021.738942
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Stankovic KM
中科院分区：
文献类型：
--
作者：
Early S;van der Valk JC;Frijns JHM;Stankovic KM
背景和介绍：特发性突发性感音神经性听力损失（ISSNHL）的特点是发病迅速，通常为单侧表现，恢复不稳定。这项病例对照观察性研究旨在通过在最大规模的ISSNHL患者队列中使用序贯测听客观表征ISSNHL后的长期听力损失进展来改善患者咨询。方法：对1994年至2018年在三级转诊医院诊断为ISSNHL的患者进行了序贯测听研究。感音神经性听力损失（SNHL）的病例对照按年龄、性别、基线听力状态和序贯测听频率进行匹配。使用Kaplan-Meier（K-M）分析量化听力损失进展，以解释可变的随访时间。根据年龄、性别、既存合并症、ISSNHL相关症状、ISSNHL治疗和ISSNHL后听力恢复程度进行亚组分析。结果：共660例患者被确定为ISSNHL。在ISSNHL后恢复至良好听力的患者中[纯音平均值（PTA）<30 dB且单词识别评分（WRS）> 70%]，进展至不可用（PTA > 50 dB或WRS <50%）SNHL的中位时间为16.4年。在ISSNHL后听力恢复不完全的患者中，在接下来的12年内，对侧耳的SNHL进展风险也显著更高。5年随访时，男性与SNHL进展风险增加相关[男性与女性的比值比（OR）为3.45]。没有其他亚组因素影响SNHL进展的可能性。讨论和结论：应告知患者ISSNHL术后听力稳定后对长期听力的持续风险，特别强调同侧恢复不完全的患者对侧耳的风险更大。
Background and Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is characterized by rapid onset, typically unilateral presentation, and variable recovery. This case-control observational study aimed to improve patient counseling by objectively characterizing long-term hearing loss progression following ISSNHL, using sequential audiometry in the largest-to-date cohort of patients with ISSNHL. Methods: Patients diagnosed with ISSNHL at a tertiary referral hospital from 1994 through 2018 with sequential audiometry were studied. Case controls with sensorineural hearing loss (SNHL) were matched by age, sex, baseline hearing status, and frequency of sequential audiometry. Hearing loss progression was quantified using Kaplan–Meier (K–M) analysis to account for variable follow-up duration. A subgroup analysis was performed by age, sex, preexisting comorbidities, ISSNHL-associated symptoms, ISSNHL treatment, and degree of post-ISSNHL hearing recovery. Results: A total of 660 patients were identified with ISSNHL. In patients with post-ISSNHL recovery to good hearing [pure tone average (PTA) <30 dB and word recognition score (WRS) > 70%], median time to progression to non-serviceable (PTA > 50 dB or WRS <50%) SNHL was 16.4 years. In patients with incomplete post-ISSNHL hearing recovery, contralateral ears were also at significantly higher risk of SNHL progression over the following 12-year period. Male sex was associated with increased risk of SNHL progression [odds ratio (OR) 3.45 male vs. female] at 5-year follow up. No other subgroup factors influenced the likelihood of SNHL progression. Discussion and Conclusion: Patients should be counseled on continued risk to long-term hearing after stabilization of hearing post-ISSNHL, with particular emphasis on greater risk to the contralateral ear in those with incomplete ipsilateral recovery.
登录
查看更多内容
影响因子：
2.6
作者：
Harkonen, Kati;Kivekas, Ilkka;Vasama, Juha-Pekka
通讯作者：
Vasama, Juha-Pekka
DOI：
10.14639/0392-100x-1614
发表时间：
2018-10
期刊：
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
影响因子：
--
作者：
Attanasio G;Russo FY;Di Porto E;Cagnoni L;Masci E;Ralli M;Greco A;De Vincentiis M
通讯作者：
De Vincentiis M
影响因子：
2.1
作者：
Halpin, C;Rauch, SD
通讯作者：
Rauch, SD
影响因子：
2.1
作者：
Jourdy, Deya N.;Donatelli, Luke A.;Selesnick, Samuel H.
通讯作者：
Selesnick, Samuel H.
影响因子：
1.6
作者：
Lin, Herng-Ching;Lee, Hsin-Chien;Wu, Chuan-Song
通讯作者：
Wu, Chuan-Song