Prenatal noise stress impairs HPA axis and cognitive performance in mice.
Prenatal noise stress impairs HPA axis and cognitive performance in mice.
复制标题
DOI：
10.1038/s41598-017-09799-6
复制
发表时间：
2017-09-05
影响因子：
4.6
通讯作者：
Mohajerani MH
中科院分区：
文献类型：
--
作者：
Jafari Z;Mehla J;Kolb BE;Mohajerani MH
噪声胁迫是一种常见的环境污染物，对子代生产性能的影响研究较少。本研究新颖地将“噪音”作为产前应激与生理应激相比较，探讨妊娠期应激对HPA轴激活、认知表现和运动协调的影响，以及行为评估对皮质酮（CORT）水平的影响。选取妊娠期有噪声应激（NS）、生理应激（PS）和无应激的三组C57BL/6小鼠进行行为学实验。NS组在开始行为测试前血浆CORT水平明显高于其他两组。在产前压力组和对照组的行为测试后，它明显增加。与对照组相比，压力导致两组压力组的焦虑样行为和学习和记忆表现下降，并且相对于其他组，NS组的运动协调能力下降。结果表明：产前NS严重改变下丘脑轴；两种产前应激源，尤其是神经性应激源，都会对后代的认知和运动表现产生负面影响；而且，它们也会导致一种强烈的易感性，将环境体验解释为压力条件。
Noise stress is a common environmental pollutant whose adverse effect on offspring performance has been less studied. This study was novel in terms of using “noise” as a prenatal stress compared with physical stress to explore the effect of stress during gestation on HPA axis activation, cognitive performance, and motor coordination, as well as in investigating the effect of behavioral assessments on the corticosterone (CORT) levels. Three groups of C57BL/6 mice with a gestational history of either noise stress (NS), physical stress (PS), or no stress were examined in several behavioral tests. Plasma CORT level was significantly higher before starting the behavioral tests in NS group than the two other groups. It was significantly increased after the behavioral tests in both prenatal stressed groups relative to the controls. Stress caused anxiety-like behavior and reduced learning and memory performance in both stressed groups compared to the controls, as well as decreased motor coordination in the NS group relative to the other groups. The findings suggested that: prenatal NS severely changes the HPA axis; both prenatal stressors, and particularly NS, negatively impair the offspring’s cognitive and motor performance; and, they also cause a strong susceptibility to interpret environmental experiences as stressful conditions.
登录
查看更多内容
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.3109/10253890.2014.954104
发表时间：
2014-12-01
影响因子：
2.3
作者：
Browne, Caroline A.;Hanke, Joachim;Yilmazer-Hanke, Deniz
通讯作者：
Yilmazer-Hanke, Deniz
影响因子：
6.9
作者：
Golde, WT;Gollobin, P;Rodriguez, LL
通讯作者：
Rodriguez, LL
影响因子：
4.4
作者：
de Souza, Marcelo Alves;Centenaro, Ligia Aline;Lucion, Aldo Bolten
通讯作者：
Lucion, Aldo Bolten
影响因子：
6
作者：
Chang, Ta-Yuan;Beelen, Rob;Liu, Chiu-Shong
通讯作者：
Liu, Chiu-Shong