HGF and MET: From Brain Development to Neurological Disorders.
HGF and MET: From Brain Development to Neurological Disorders.
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DOI：
10.3389/fcell.2021.683609
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发表时间：
2021
影响因子：
5.5
通讯作者：
Crepaldi T
中科院分区：
文献类型：
--
作者：
Desole C;Gallo S;Vitacolonna A;Montarolo F;Bertolotto A;Vivien D;Comoglio P;Crepaldi T
肝细胞生长因子（HGF）及其酪氨酸激酶受体（由MET细胞原癌基因编码）从出生前发育到成年在神经系统中表达，参与神经元的生长和存活。在这篇综述中，我们强调，除了神经营养作用，新的作用HGF-MET在突触发生在出生后的大脑发育和MET表达失调和发育障碍，如自闭症谱系障碍（ASD）之间的联系。在药理学方面，HGF诱导的MET活化也在成年期发挥有益的神经保护作用，特别是在神经退行性疾病中，以及在脑缺血、脊髓损伤和神经病理学（如阿尔茨海默病（AD）、肌萎缩性侧索硬化（ALS）和多发性硬化（MS））的临床前模型中。HGF是通过促血管生成、抗炎和免疫调节机制防止神经元死亡和促进存活的关键因子。最近的证据表明，HGF作用于神经干细胞以增强神经再生。可能的治疗应用肝细胞生长因子和肝细胞生长因子模拟物治疗神经系统疾病进行了讨论。
Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET cellular proto-oncogene, are expressed in the nervous system from pre-natal development to adult life, where they are involved in neuronal growth and survival. In this review, we highlight, beyond the neurotrophic action, novel roles of HGF-MET in synaptogenesis during post-natal brain development and the connection between deregulation of MET expression and developmental disorders such as autism spectrum disorder (ASD). On the pharmacology side, HGF-induced MET activation exerts beneficial neuroprotective effects also in adulthood, specifically in neurodegenerative disease, and in preclinical models of cerebral ischemia, spinal cord injuries, and neurological pathologies, such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). HGF is a key factor preventing neuronal death and promoting survival through pro-angiogenic, anti-inflammatory, and immune-modulatory mechanisms. Recent evidence suggests that HGF acts on neural stem cells to enhance neuroregeneration. The possible therapeutic application of HGF and HGF mimetics for the treatment of neurological disorders is discussed.
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DOI：
10.1016/s0165-3806(97)00108-9
发表时间：
1997-09-20
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Achim, CL;Katyal, S;Michalopoulos, GK
通讯作者：
Michalopoulos, GK
影响因子：
8
作者：
Campbell, Daniel B.;Buie, Timothy M.;Levitt, Pat
通讯作者：
Levitt, Pat
影响因子：
5.1
作者：
Aoki, M;Morishita, R;Ogihara, T
通讯作者：
Ogihara, T
影响因子：
25
作者：
通讯作者：
--
影响因子：
56.9
作者：
BOTTARO, DP;RUBIN, JS;AARONSON, SA
通讯作者：
AARONSON, SA