Methodology of AA CRASH: a prospective observational study evaluating the incidence and pathogenesis of adverse post-traumatic sequelae in African-Americans experiencing motor vehicle collision.
Methodology of AA CRASH: a prospective observational study evaluating the incidence and pathogenesis of adverse post-traumatic sequelae in African-Americans experiencing motor vehicle collision.
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DOI：
10.1136/bmjopen-2016-012222
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发表时间：
2016-09-06
期刊：
影响因子：
2.9
通讯作者：
McLean SA
中科院分区：
文献类型：
--
作者：
Linnstaedt SD;Hu J;Liu AY;Soward AC;Bollen KA;Wang HE;Hendry PL;Zimny E;Lewandowski C;Velilla MA;Damiron K;Pearson C;Domeier R;Kaushik S;Feldman J;Rosenberg M;Jones J;Swor R;Rathlev N;McLean SA
机动车碰撞（MVC）是生活在美国的个人经历的最常见的危及生命的事件之一。虽然大多数人在MVC后恢复，但很大一部分人会出现不良的创伤后后遗症，如创伤后应激障碍或持续的肌肉骨骼疼痛。在美国和其他工业化国家，不良的创伤后后遗症是常见的、病态的和昂贵的公共卫生问题。MVC后这些疾病的发病机制尚不清楚。在美国，现有数据表明，与欧洲裔美国人相比，非洲裔美国人在MVC后的不良创伤后后遗症负担增加，但迄今为止还没有研究检查这些疾病在经历MVC的非洲裔美国人中的发病机制。非裔美国人CRASH （AA CRASH）研究是美国国立卫生研究院资助的一项多中心前瞻性研究，招募了在MVC发生24小时内到急诊室就诊的非裔美国人（n=900）。参与者在美国的13个ED站点注册。被医院收治或报告骨折或组织损伤的个人被排除在外。参与者完成详细的急诊科访谈，包括对车祸史、当前创伤后症状和车祸前健康状况的评估。血液样本也收集在ED使用PAXgene DNA和PAXgene RNA管。MVC后6周、6个月和1年的连续混合模式评估包括对不良后遗症、一般健康状况和卫生服务利用情况的评估。这项研究的结果将为非洲裔美国人经历MVC的持续性疼痛和其他创伤后后遗症的发生率和发病机制提供见解。AA CRASH已在美国获得伦理批准，其结果将发表在同行评议的期刊上。
A motor vehicle collision (MVC) is one of the most common life-threatening events experienced by individuals living in the USA. While most individuals recover following MVC, a significant proportion of individuals develop adverse post-traumatic sequelae such as post-traumatic stress disorder or persistent musculoskeletal pain. Adverse post-traumatic sequelae are common, morbid and costly public health problems in the USA and other industrialised countries. The pathogenesis of these disorders following MVC remains poorly understood. In the USA, available data suggest that African-Americans experience an increased burden of adverse post-traumatic sequelae after MVC compared to European Americans, but to date no studies examining the pathogenesis of these disorders among African-Americans experiencing MVC have been performed. The African-American CRASH (AA CRASH) study is an NIH-funded, multicentre, prospective study that enrols African-Americans (n=900) who present to the emergency department (ED) within 24 hours of MVC. Participants are enrolled at 13 ED sites in the USA. Individuals who are admitted to the hospital or who report a fracture or tissue injury are excluded. Participants complete a detailed ED interview that includes an assessment of crash history, current post-traumatic symptoms and health status prior to the MVC. Blood samples are also collected in the ED using PAXgene DNA and PAXgene RNA tubes. Serial mixed-mode assessments 6 weeks, 6 months and 1 year after MVC include an assessment of adverse sequelae, general health status and health service utilisation. The results from this study will provide insights into the incidence and pathogenesis of persistent pain and other post-traumatic sequelae in African-Americans experiencing MVC. AA CRASH has ethics approval in the USA, and the results will be published in a peer-reviewed journal.
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影响因子：
7.4
作者：
Campbell, CM;Edward, RR;Fillingim, RB
通讯作者：
Fillingim, RB
影响因子：
7.4
作者：
Bortsov, Andrey V.;Smith, Jennifer E.;McLean, Samuel A.
通讯作者：
McLean, Samuel A.
影响因子：
4
作者：
Campbell, Claudia M.;France, Christopher R.;Fillingim, Roger B.
通讯作者：
Fillingim, Roger B.
DOI：
10.1016/0197-2456(95)00048-8
发表时间：
1995-10-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
FREEDMAN, LS;SIMON, R;MOWERY, R
通讯作者：
MOWERY, R
影响因子：
3.3
作者：
Edwards, RR;Doleys, DM;Lowery, D
通讯作者：
Lowery, D