Measurement of mismatch negativity in individuals: a study using single-trial analysis.

Measurement of mismatch negativity in individuals: a study using single-trial analysis.
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DOI:
10.1111/j.1469-8986.2009.00970.x
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发表时间:
2010-07-01
期刊:
影响因子:
3.7
通讯作者:
Hardiman MJ
Hardiman MJ
中科院分区:
心理学3区
文献类型:
--
作者:
Bishop DV;Hardiman MJ

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失配负波(MMN)是通过从对罕见异常刺激的平均反应中减去对一组标准刺激的平均反应,并在给定的时间窗口中获取该差异波的幅度来测量的。当用于评估个体时,这种方法是有问题的,因为没有方差的估计。我们描述了一种新的方法,在该方法中,独立的成分与高试验的试验方差首先被删除。接下来,每个偏差响应都减去前一个标准响应,得到一组单次试验差异波。我们说明这种方法在MMN的分析,以简短的音调在17个成年人。MMN的最佳标准结合了t检验和试验间一致性指数,在14个(82%)个体中给出了显著的MMN。单次试验方法可以表明哪些人显示MMN。然而,在一些临床正常的人有没有MMN,尽管良好的行为歧视的刺激。
Mismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because there is no estimate of variance. We describe a new approach, in which independent components with high trial-by-trial variance are first removed. Next, each deviant response has the preceding standard response subtracted, giving a set of single trial difference waves. We illustrate this approach in analysis of MMN to brief tones in 17 adults. The best criterion for MMN combined t-test with an index of inter-trial coherence, giving significant MMN in 14 (82%) of individuals. Single-trial methods can indicate which people show MMN. However, in some clinically normal individuals there was no MMN, despite good behavioral discrimination of stimuli.
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