Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients.
Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients.
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DOI：
10.1186/1471-2407-11-210
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发表时间：
2011-05-30
期刊：
影响因子：
3.8
通讯作者：
Piché A
中科院分区：
文献类型：
--
作者：
Lane D;Matte I;Rancourt C;Piché A
上皮性卵巢癌（EOC）腹水的无细胞部分促进肿瘤细胞的从头抗性，因此支持肿瘤细胞可以在周围保护性微环境中存活从而有助于疾病复发的观点。促炎细胞因子IL-6和IL-8的水平在EOC腹水中升高，表明它们可能在肿瘤进展中起作用。我们检测了39例初治卵巢癌患者腹水中IL-6和IL-8的水平。采用市售酶联免疫吸附试验（ELISA）测定IL-6和IL-8腹水水平。腹水细胞因子水平与临床病理参数和无进展生存期相关。IL-6和IL-8的平均腹水水平分别为6419 pg/ml（SEM：1409 pg/ml）和1408 pg/ml（SEM：437 pg/ml）。术前接受过化疗的患者腹水中IL-6和IL-8水平显著较低（Mann-Whitney U检验，IL-6 P = 0.037，IL-8 P = 0.008）。单变量分析显示，高IL-6腹水水平（P = 0.021）、血清CA 125水平（P = 0.04）和IV期（P = 0.009）与较短的无进展生存期显着相关。在多变量分析中包括这些变量，显示IL-6水平升高（P = 0.033）是无进展生存期较短的独立预测因子。IL-6，而不是IL-8，腹水水平升高是无进展生存期较短的独立预测因子。
The acellular fraction of epithelial ovarian cancer (EOC) ascites promotes de novo resistance of tumor cells and thus supports the idea that tumor cells may survive in the surrounding protective microenvironment contributing to disease recurrence. Levels of the pro-inflammatory cytokines IL-6 and IL-8 are elevated in EOC ascites suggesting that they could play a role in tumor progression. We measured IL-6 and IL-8 levels in the ascites of 39 patients with newly diagnosed EOC. Commercially available enzyme-linked immunosorbent assay (ELISA) was used to determine IL-6 and IL-8 ascites levels. Ascites cytokine levels were correlated with clinicopathological parameters and progression-free survival. Mean ascites levels for IL-6 and IL-8 were 6419 pg/ml (SEM: 1409 pg/ml) and 1408 pg/ml (SEM: 437 pg/ml) respectively. The levels of IL-6 and IL-8 in ascites were significantly lower in patients that have received prior chemotherapy before the surgery (Mann-Whitney U test, P = 0.037 for IL-6 and P = 0.008 for IL-8). Univariate analysis revealed that high IL-6 ascites levels (P = 0.021), serum CA125 levels (P = 0.04) and stage IV (P = 0.009) were significantly correlated with shorter progression-free survival. Including these variables in a multivariate analysis revealed that elevated IL-6 levels (P = 0.033) was an independent predictor of shorter progression-free survival. Elevated IL-6, but not IL-8, ascites level is an independent predictor of shorter progression-free survival.
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