Sex-specific neural responses to acute psychosocial stress in depression.
Sex-specific neural responses to acute psychosocial stress in depression.
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DOI：
10.1038/s41398-021-01768-y
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发表时间：
2022-01-10
影响因子：
6.8
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Dong D;Ironside M;Belleau EL;Sun X;Cheng C;Xiong G;Nickerson LD;Wang X;Yao S;Pizzagalli DA
重度抑郁症（MDD）的特征是压力敏感性增加。在健康成年人中的新发现表明，边缘系统/纹状体-前额叶区域内的压力反应受性别的调节，并随着时间的推移而展开。因此，我们假设抑郁症的应激反应异常可能受到性别和应激暴露时间的影响。在功能性磁共振成像（fMRI）期间，对124名首次发作MDD的未用药患者（76名女性）和243名健康对照（HC; 137名女性）进行蒙特利尔成像应激任务。在前人研究的基础上，选择杏仁核、海马、内侧眶额皮质（mOFC）、前额叶核（NAc）和背外侧前额叶皮质（dlPFC）作为先验感兴趣区域。在一个互补的方法，我们探讨了压力的影响额顶网络（FPN）和网络，包括杏仁核，NAC和前扣带皮层（ACC）。在各组中，雄性动物的dlPFC活性和右侧FPN振幅均高于雌性动物。相对于女性HC，女性MDD组在边缘/纹状体区域（杏仁核、NAc、海马、杏仁核-NAc-ACC网络）中的失活较少。此外，不像女性HC，女性MDD组未能显示出显着增加的失活应激暴露时间在杏仁核，mOFC和NAC。我们的研究结果证实了在研究神经应激反应时考虑性别差异的重要性。在女性（而非男性）中观察到的神经应激反应的病例对照差异为抑郁症的病因学和病理生理学的性别差异提供了见解。抑郁症女性的边缘/NAc区域失活失败表明，在压力暴露时间内，适应性压力反应功能障碍。
Major Depressive Disorder (MDD) is characterized by increased stress sensitivity. Emerging findings in healthy adults suggest that stress responses within limbic/striatal-prefrontal regions are moderated by sex and unfold over time. Thus, we hypothesized that stress response abnormalities in MDD might be affected by sex and stress exposure time. The Montreal Imaging Stress Task was administered to 124 unmedicated patients with first-episode MDD (76 females) and 243 healthy controls (HC; 137 females) during functional magnetic resonance imaging (fMRI). Based on prior studies, amygdala, hippocampus, medial orbitofrontal cortex (mOFC), nucleus accumbens (NAc) and dorsolateral prefrontal cortex (dlPFC) were selected as a priori regions of interest. In a complementary approach, we probed the effects of stress on the frontoparietal network (FPN) and a network including the amygdala, NAc and anterior cingulate cortex (ACC). Across groups, males exhibited higher dlPFC activity and right FPN amplitude than females. Relative to female HCs, the female MDD group had less deactivation in limbic/striatal regions (amygdala, NAc, hippocampus, Amygdala-NAc-ACC network). Furthermore, unlike female HCs, the female MDD group failed to show a significant increase of deactivation over stress exposure time in the amygdala, mOFC and NAc. Our findings confirm the importance of considering sex differences when investigating neural stress responses. Case-control differences in neural stress responses observed in females (but not males) provide insights into sex differences in the etiology and pathophysiology of depression. The failure to deactivate limbic/NAc regions in depressed females point to dysfunction of adaptive stress responses over stress exposure time.
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DOI：
10.1016/j.nicl.2020.102543
发表时间：
2021
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Corr R;Pelletier-Baldelli A;Glier S;Bizzell J;Campbell A;Belger A
通讯作者：
Belger A
影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
4.8
作者：
Kogler, Lydia;Gur, Ruben C.;Derntl, Birgit
通讯作者：
Derntl, Birgit
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.