Neural mechanisms of acute stress and trait anxiety in adolescents.
Neural mechanisms of acute stress and trait anxiety in adolescents.
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DOI：
10.1016/j.nicl.2020.102543
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Belger A
中科院分区：
文献类型：
--
作者：
Corr R;Pelletier-Baldelli A;Glier S;Bizzell J;Campbell A;Belger A
蒙特利尔想象压力任务是一种有效的青少年急性压力源。急性应激暴露影响青少年脑激活的fMRI测量。急性应激时海马神经元失活与皮质醇释放有关。特质焦虑与应激相关的海马体、VS和壳核活动有关。男性表现出更大的壳核失活在急性应激比女性。青春期是一个关键时期，高度的压力敏感性和高度的脆弱性发展的精神疾病，这表明压力暴露和精神疾病的病因之间可能存在关联。在成年人中，对急性应激的异常神经生物学反应与焦虑症状有关，但对青少年的神经应激反应及其与生物和心理变量的关系知之甚少。在这里，我们使用多种方式，包括神经影像学，主观压力评级，心率和皮质醇数据的特点在青少年的压力反应的神经生物学。我们使用蒙特利尔成像应激任务（MIST）评估青少年的应激反应，MIST是一种在成人功能性磁共振成像（fMRI）研究中常用的急性心理社会应激源，但以前未用于该人群。101名青少年（44名女性; 9-16岁）表现出不同的特质焦虑严重程度的功能磁共振成像数据。MIST引起高频心率变异性降低，心率、主观压力和皮质醇增加。全脑分析比较实验与对照MIST条件下的功能磁共振成像活动显示，包括前额叶皮层，背侧前扣带皮层，背外侧前额叶皮层和失活的海马，腹侧纹状体和壳核的区域与压力相关的激活。感兴趣区域分析发现，在急性应激期间，（a）海马失活对应于皮质醇释放增加，（B）特质焦虑与海马和腹侧纹状体激活增加和壳核活性降低相关，（c）男性比女性表现出更大的壳核失活。这些结果提供了新的证据，MIST是一个有效的压力源，青少年。神经急性应激反应，其他生物学因素和特质焦虑之间的关联突出了这些神经生物学机制在理解焦虑症中的重要性。
The Montreal Imaging Stress Task is an effective acute stressor for adolescents. Acute stress exposure impacts fMRI measures of brain activation in adolescents. Hippocampal deactivation during acute stress is associated with cortisol release. Trait anxiety is linked to stress-related hippocampus, VS, and putamen activity. Males exhibit greater putamen deactivation during acute stress than females. Adolescence is a critical period of heightened stress sensitivity and elevated vulnerability for developing mental illness, suggesting a possible association between stress exposure and the etiology of psychiatric disorders. In adults, aberrant neurobiological responses to acute stress relate to anxiety symptoms, yet less is known about the neural stress response in adolescents and how it relates to biological and psychological variables. Here we characterize the neurobiology of stress response in adolescents using multiple modalities, including neuroimaging, subjective stress ratings, heart rate, and cortisol data. We evaluated stress response in adolescents using the Montreal Imaging Stress Task (MIST), an acute psychosocial stressor commonly administered in adult functional magnetic resonance imaging (fMRI) studies but not previously utilized with this population. FMRI data were acquired from 101 adolescents (44 female; 9–16 years) exhibiting varied trait anxiety severity. The MIST elicited decreased high-frequency heart rate variability and increased heart rate, subjective stress and cortisol. Whole-brain analyses comparing fMRI activity during experimental versus control MIST conditions revealed stress-related activation in regions including the anterior insula, dorsal anterior cingulate cortex, and dorsolateral prefrontal cortex and deactivations in the hippocampus, ventral striatum, and putamen. Region of Interest analyses found that during acute stress (a) hippocampal deactivation corresponded to heightened cortisol release, (b) trait anxiety was associated with increased hippocampal and ventral striatum activation and decreased putamen activity, and (c) males exhibited greater putamen deactivation than females. These results provide novel evidence that the MIST is an effective stressor for adolescents. Associations between the neural acute stress response, other biological factors, and trait anxiety highlight the importance of these neurobiological mechanisms in understanding anxiety disorders.
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影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
4.8
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3
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通讯作者：
Potenza, Marc N.
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.