Viral diseases of the central nervous system.

Viral diseases of the central nervous system.
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DOI:
10.1016/j.coviro.2014.12.009
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发表时间:
2015-04
影响因子:
5.9
通讯作者:
McGavern, Dorian B.
McGavern, Dorian B.
中科院分区:
医学2区
文献类型:
--
作者:
Swanson, Phillip A., II;McGavern, Dorian B.

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病毒引起的中枢神经系统(CNS)疾病对全世界人类健康构成重大负担。这些疾病的复杂性受到不同嗜神经病毒的数量、进入中枢神经系统的不同途径、病毒趋向性和免疫系统的影响。通过结合人类病理数据和实验动物模型,我们已经开始揭示病毒进入中枢神经系统并引起疾病的许多机制。这篇综述重点介绍了一系列感染中枢神经系统的嗜神经病毒,并探讨了它们诱发脑膜炎、脑炎和脊髓炎等神经系统疾病的方式。
Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system. Using a combination of human pathological data and experimental animal models, we have begun to uncover many of the mechanisms that viruses use to enter the CNS and cause disease. This review highlights a selection of neurotropic viruses that infect the CNS and explores the means by which they induce neurological diseases such as meningitis, encephalitis, and myelitis.
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