Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption.
Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption.
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DOI：
10.1016/j.scitotenv.2017.07.056
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发表时间：
2017-12-31
期刊：
影响因子：
--
通讯作者：
Boyd WA
中科院分区：
文献类型：
--
作者：
Lunn RM;Blask DE;Coogan AN;Figueiro MG;Gorman MR;Hall JE;Hansen J;Nelson RJ;Panda S;Smolensky MH;Stevens RG;Turek FW;Vermeulen R;Carreón T;Caruso CC;Lawson CC;Thayer KA;Twery MJ;Ewens AD;Garner SC;Schwingl PJ;Boyd WA
电灯的发明促进了社会的发展，在这个社会里，人们24小时不间断地工作、睡觉、吃饭和娱乐。虽然电灯显然有益于人类，但暴露于电灯，特别是夜间灯光（LAN），可能会破坏由内源性生物钟控制的睡眠和生物过程，可能导致不利的健康结果。许多评估不良健康影响的研究都是在夜班和夜班工人中进行的，因为这种情况会导致大量的局域网暴露。由于这一主题的复杂性，国家毒理学计划在一个题为“夜间轮班工作，夜间人工光和昼夜节律中断”的公共研讨会上召集了一个专家小组，以获得关于进行基于文献的健康危害评估的意见，并确定数据差距和研究需求。专家组建议将光描述为内源性生物钟和节律的直接效应器，以及可能导致生物钟紊乱的额外活动或行为的促成因素，例如夜班工作和可能导致社交时差的非典型和不一致的睡眠-觉醒模式。未来的研究应该更全面地描述和测量相关的光相关暴露，并将这些暴露与昼夜节律紊乱的时间无关生物标志物和不良健康结果的生物标志物联系起来。这些信息应有助于改进人类流行病学和动物或体外模型，更严格地进行健康危害评估，并制定干预战略，尽量减少这些接触造成的不良健康后果。
The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-shift workers, because this scenario gives rise to significant exposure to LAN. Because of the complexity of this topic, the National Toxicology Program convened an expert panel at a public workshop entitled “Shift Work at Night, Artificial Light at Night, and Circadian Disruption” to obtain input on conducting literature-based health hazard assessments and to identify data gaps and research needs. The Panel suggested describing light both as a direct effector of endogenous circadian clocks and rhythms and as an enabler of additional activities or behaviors that may lead to circadian disruption, such as night-shift work and atypical and inconsistent sleep-wake patterns that can lead to social jet lag. Future studies should more comprehensively characterize and measure the relevant light-related exposures and link these exposures to both time-independent biomarkers of circadian disruption and biomarkers of adverse health outcomes. This information should lead to improvements in human epidemiological and animal or in vitro models, more rigorous health hazard assessments, and intervention strategies to minimize the occurrence of adverse health outcomes due to these exposures.
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影响因子：
3.7
作者：
Blask DE;Dauchy RT;Dauchy EM;Mao L;Hill SM;Greene MW;Belancio VP;Sauer LA;Davidson L
通讯作者：
Davidson L
影响因子：
4.9
作者：
Hansen, Johnni;Lassen, Christina F.
通讯作者：
Lassen, Christina F.
夜间暴露在光线下造成的昼夜节律和褪黑激素的破坏会导致乳腺癌对他莫昔芬治疗产生内在耐药性。
影响因子：
11.2
作者：
Dauchy RT;Xiang S;Mao L;Brimer S;Wren MA;Yuan L;Anbalagan M;Hauch A;Frasch T;Rowan BG;Blask DE;Hill SM
通讯作者：
Hill SM
DOI：
10.1002/jez.1877
发表时间：
2014-10-01
影响因子：
2.8
作者：
Aubrecht, Taryn G.;Weil, Zachary M.;Nelson, Randy J.
通讯作者：
Nelson, Randy J.
影响因子：
3.3
作者：
Bedrosian, Tracy A.;Fonken, Laura K.;Nelson, Randy J.
通讯作者：
Nelson, Randy J.