Dynamic Changes in Serum Leptin Concentrations during the Fetal and Neonatal Periods
Dynamic Changes in Serum Leptin Concentrations during the Fetal and Neonatal Periods
复制标题
胎儿期和新生儿期血清瘦素浓度的动态变化
作者：
J. Matsuda;I. Yokota;M. Iida;T. Murakami;M. Yamada;T. Saijo;E. Naito;Michinori Ito;K. Shima;Y. Kuroda
我们调查了整个围产期瘦素浓度的动态。本文测定了20例早产儿、139例足月新生儿、143例孕妇和24例出生后6 d左右的足月新生儿的脐带血瘦素水平。早产儿血清瘦素水平（4.6 ± 6.9 ng/mL）低于足月儿（19.6 ± 14.3 ng/mL），且随着胎龄和出生体重的增加，瘦素水平有升高的趋势，尤其是从妊娠晚期开始。孕妇的瘦素浓度从第一个三个月开始增加，然后在整个怀孕的剩余时间内保持高于非孕妇，即使在控制体重指数后。新生儿的瘦素浓度迅速下降，到出生后约6天时已降至极低水平（平均1.9 ± 1.1 ng/mL）。这些结果表明，胎儿可能会产生一部分循环瘦素在自己的脂肪细胞和相对较高的瘦素浓度在出生时和新生儿早期的快速下降可能反映了显着的变化，激素和营养状态在围产期。
We investigated the dynamics of the leptin concentration throughout the perinatal period. Serum leptin concentrations in venous cord blood at different gestational ages were measured in 20 preterm and 139 term newborns, as well as in 143 pregnant women and 24 term newborns at approximately 6 d of life. Leptin concentrations in preterm newborns (mean 4.6 ± 6.9 ng/mL) were lower than those in term newborns (mean 19.6 ± 14.3 ng/mL) and tended to increase according to gestational age and birth weight, especially from the late stage of gestation. Leptin concentrations in pregnant women increased from the first trimester and then remained higher than those in non-pregnant women throughout the remainder of pregnancy even after controlling for body mass index. The leptin concentrations of newborns declined rapidly and were extremely low by approximately 6 d of life (mean 1.9 ± 1.1 ng/mL). These results suggest that fetuses might produce a part of circulating leptin in their own adipocytes and that the relatively high leptin concentrations at birth and their rapid decline in the early neonatal period might reflect the dramatic changes of the hormonal and nutritional state during the perinatal period.
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影响因子：
56.9
作者：
HALAAS, JL;GAJIWALA, KS;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM
影响因子：
158.5
作者：
Considine, RV;Sinha, MK;Caro, JF
通讯作者：
Caro, JF
影响因子：
7
作者：
GREEN, ED;MAFFEI, M;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM
瘦素对人类短期和长期过度喂养的反应。
DOI：
10.1210/jcem.81.11.8923877
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Kolaczynski,JW;Ohannesian,JP;Considine,RV;Marco,CC;Caro,JF
通讯作者：
Caro,JF