Novel controlled and targeted releasing hydrogen sulfide system exerts combinational cerebral and myocardial protection after cardiac arrest.
Novel controlled and targeted releasing hydrogen sulfide system exerts combinational cerebral and myocardial protection after cardiac arrest.
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新型可控靶向释放硫化氢系统在心脏骤停后发挥脑和心肌联合保护作用
DOI：
10.1186/s12951-021-00784-w
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发表时间：
2021-02-06
影响因子：
10.2
通讯作者：
Pang L
中科院分区：
文献类型：
--
作者：
Sun X;Wang Y;Wen S;Huang K;Huang J;Chu X;Wang F;Pang L
背景心脏骤停（Cardiac arrest，CA）是世界范围内的主要死亡原因。即使在成功的心肺复苏（CPR）后，大多数存活者仍伴有永久性的心肌和脑损伤。硫化氢（H2S）是一种新型的气体递质，具有多器官保护作用;结果以介孔氧化铁纳米粒子（MION）为载体，制备了二烯丙基三硫化物（DATS），将聚乙二醇（PEG）和乳铁蛋白（LF）修饰到MIONs上，以获得延长循环时间和脑靶向效应，构建了一种新型的靶向H2S释放系统（DATS@MION-PEG-LF），其表现出优异的生物相容性、受控释放H2S模式、心脏和脑靶向特征以及通过磁共振成像非侵入性追踪的能力。DATS@MION-PEG-LF对体外缺氧/复氧模型和在体CA/CPR模型CA后脑、心缺血损伤均有明显的保护作用，其机制主要涉及抗凋亡、抗炎和抗氧化。因此，心和脑功能明显改善后CA/CPR，与潜在的改善survival.ConclusionsThe目前的工作提供了一个独特的平台，靶向控制释放H2S的基础上MIONs，并提供了一种新的方法，联合心肌和脑缺血损伤的保护，为CA患者带来相当大的好处。
BackgroundCardiac arrest (CA) is a leading cause of death worldwide. Even after successful cardiopulmonary resuscitation (CPR), the majorities of survivals are companied with permanent myocardial and cerebral injury. Hydrogen sulfide (H2S) has been recognized as a novel gasotransmitter exerting multiple organ protection; however, the lacks of ideal H2S donors which can controlled release H2S to targeted organs such as heart and brain limits its application.ResultsThis work utilized mesoporous iron oxide nanoparticle (MION) as the carriers of diallyl trisulfide (DATS), with polyethylene glycol (PEG) and lactoferrin (LF) modified to MIONs to acquire the prolonged circulation time and brain-targeting effects, and a novel targeted H2S releasing system was constructed (DATS@MION-PEG-LF), which exhibited excellent biocompatibility, controlled-releasing H2S pattern, heart and brain targeting features, and the ability to be non-invasive traced by magnetic resonance imaging. DATS@MION-PEG-LF presented potent protective effects against cerebral and cardiac ischemic injury after CA in bothin vitrohypoxia/reoxygenation models andin vivoCA/CPR models, which mainly involves anti-apoptosis, anti-inflammatory and anti-oxidant mechanisms. Accordingly, the cardiac and cerebral functions were obviously improved after CA/CPR, with potentially improved survival.ConclusionsThe present work provides a unique platform for targeted controlled release of H2S based on MIONs, and offers a new method for combinational myocardial and cerebral protection from ischemic injury, bringing considerable benefits for CA patients.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
4.7
作者：
Vandiver, M. Scott;Snyder, Solomon H.
通讯作者：
Snyder, Solomon H.
影响因子：
8
作者：
Katebi, Samira;Esmaeili, Abolghasem;Zarrabi, Ali
通讯作者：
Zarrabi, Ali
影响因子：
10.8
作者：
Paulis, Leonie E.;Geelen, Tessa;Strijkers, Gustav J.
通讯作者：
Strijkers, Gustav J.
影响因子：
6.3
作者：
Huang, Rongqin;Ke, Weilun;Pei, Yuanying
通讯作者：
Pei, Yuanying