Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach.
Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach.
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DOI：
10.1371/journal.pone.0039545
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kato J
中科院分区：
文献类型：
--
作者：
Yoshida M;Takimoto R;Murase K;Sato Y;Hirakawa M;Tamura F;Sato T;Iyama S;Osuga T;Miyanishi K;Takada K;Hayashi T;Kobune M;Kato J
由于其侵袭性和缺乏有效的治疗方法，胰腺导管腺癌预后不佳。因此，迫切需要新的策略来改善治疗和生存率。血清中众多的聚焦抗原可作为肿瘤标志物，用于肿瘤检测和治疗效果评估。胰腺癌中focusyltransferases的表达增加也有报道。这些酶通过唾液化前体的聚焦加速恶性转化，这表明胰腺癌细胞对聚焦有重要的要求。考虑到这一点，我们开发了聚焦结合纳米颗粒作为抗癌药物特异性递送到癌细胞的载体。含有Cy5.5或顺铂的L-聚焦结合脂质体被有效地递送到表达CA19-9的胰腺癌细胞中。过量的L-聚焦降低了L-聚焦结合脂质体引入Cy5.5的效率，提示L-聚焦受体介导的传递。在小鼠异种移植模型中，静脉注射携带顺铂的L-病灶结合脂质体成功递送到胰腺癌细胞，介导有效的肿瘤生长抑制并延长生存期。这种模式代表了胰腺癌细胞靶向治疗的新策略。
Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required. Numerous fucosylated antigens in sera serve as tumor markers for cancer detection and evaluation of treatment efficacy. Increased expression of fucosyltransferases has also been reported for pancreatic cancer. These enzymes accelerate malignant transformation through fucosylation of sialylated precursors, suggesting a crucial requirement for fucose by pancreatic cancer cells. With this in mind, we developed fucose-bound nanoparticles as vehicles for delivery of anticancer drugs specifically to cancer cells. L-fucose-bound liposomes containing Cy5.5 or Cisplatin were effectively delivered into CA19-9 expressing pancreatic cancer cells. Excess L-fucose decreased the efficiency of Cy5.5 introduction by L-fucose-bound liposomes, suggesting L-fucose-receptor-mediated delivery. Intravenously injected L-fucose-bound liposomes carrying Cisplatin were successfully delivered to pancreatic cancer cells, mediating efficient tumor growth inhibition as well as prolonging survival in mouse xenograft models. This modality represents a new strategy for pancreatic cancer cell-targeting therapy.
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影响因子：
37.3
作者：
Keleg, Shereen;Buchler, Peter;Ludwig, Roman;Buchler, Markus W;Friess, Helmut
通讯作者：
Friess, Helmut
影响因子：
56.9
作者：
KOPROWSKI, H;HERLYN, M;SEARS, HF
通讯作者：
SEARS, HF
影响因子：
3.6
作者：
GUNN, FJ;TATE, CG;HENDERSON, PJF
通讯作者：
HENDERSON, PJF
DOI：
10.1016/s0304-4165(00)00163-x
发表时间：
2000-12-15
影响因子：
3
作者：
Kawakami, S;Wong, J;Hashida, M
通讯作者：
Hashida, M
影响因子：
45.3
作者：
Moore, Malcolm J.;Goldstein, David;Parulekar, Wendy
通讯作者：
Parulekar, Wendy