Tumor‐induced osteomalacia combined with acromegaly: A case report
Tumor‐induced osteomalacia combined with acromegaly: A case report
复制标题
肿瘤诱发的骨软化症合并肢端肥大症：一例报告
DOI：
10.1111/nyas.14893
复制
发表时间：
2022-09
影响因子：
5.2
通讯作者：
Weibo Xia
中科院分区：
文献类型：
--
作者：
Xiang Li;Xiaolin Ni;Xiaofeng Chai;Linjie Wang;Yan Jiang;Hongli Jing;Li Huo;Huanwen Wu;Yong Yao;Jin Jin;Bin Feng;Yu Xia;Wei Yu;Yue Chi;Wei Liu;Qianqian Pang;Lijia Cui;Ruizhi Jiajue;Yiyi Gong;Ou Wang;Mei Li;Xiaoping Xing;Weibo Xia
肢端肥大症和肿瘤诱导的骨软化症（TIO）都是由神经内分泌肿瘤分泌的过量激素引起的罕见疾病，这些激素分别是生长激素（GH）和成纤维细胞生长因子23（FGF 23）。GH通过胰岛素样因子1（IGF-1）的作用提高磷酸盐重吸收，而FGF 23抑制磷酸盐重吸收并显著降低血清磷酸盐水平。一位具有典型肢端肥大症外观，但伴有身高下降及低磷血症2年的患者来我院就诊。实验室检查显示GH和IGF-1分泌过多，以及肾性磷酸盐消耗引起的低磷酸盐血症。磁共振影像显示为垂体生长激素腺瘤。Octreoscan动脉造影也发现了一个肿瘤的病因右脚低磷酸盐血症。然后，他接受了右脚肿瘤切除术。他的血磷立即恢复正常，但逐渐升高。然后，我们切除了患者的垂体腺瘤，GH和磷酸盐水平恢复到正常范围。在这里，我们报告了第一例肢端肥大症合并TIO，他的磷酸盐浓度的变化过程表明，在这种罕见的情况下，过量的GH和FGF 23的一个有趣的并发作用。
Both acromegaly and tumor-induced osteomalacia (TIO) are rare diseases caused by an excess hormone secreted by neuroendocrine neoplasms, which are growth hormone (GH) and fibroblast growth factor 23 (FGF23), respectively. GH elevates phosphate reabsorption via the effect of insulin-like factor 1 (IGF-1), while FGF23 inhibits phosphate reabsorption and reduces serum phosphate level markedly. A patient who developed a typical acromegaly appearance but was accompanied with height loss and hypophosphatemia for 2 years visited our hospital. Laboratory investigations showed GH and IGF-1 hypersecretion, as well as hypophosphatemia caused by renal phosphate wasting. Magnetic resonance image revealed a pituitary somatotroph adenoma. Octreoscan scintigraphy also found a causative tumor on the right foot for hypophosphatemia. Then, he underwent resection of the tumor on the right foot. His serum phosphate returned to normal immediately but elevated gradually. Then, we removed the pituitary adenoma of the patient, and the GH and phosphate levels returned to the normal range. Here, we report the first case with acromegaly combined with TIO, the changing process of his phosphate concentration suggests an interesting concurrent effect of excess GH and FGF23 in this rare condition.
登录
查看更多内容
影响因子：
--
作者：
Lewiecki, E. Michael;Urig, Edward J., Jr.;Williams, Ralph C., Jr.
通讯作者：
Williams, Ralph C., Jr.
生长激素在健康和肾脏疾病中的肾作用。
DOI：
10.1007/s00467-021-05097-6
发表时间：
2021-08
期刊：
Pediatric nephrology (Berlin, Germany)
影响因子：
--
作者：
Haffner D;Grund A;Leifheit-Nestler M
通讯作者：
Leifheit-Nestler M
影响因子：
6.2
作者：
E. Solary;I. Velay;B. Chauffert;J. Bidan;D. Caillot;M. Dumas;H. Guy
通讯作者：
E. Solary;I. Velay;B. Chauffert;J. Bidan;D. Caillot;M. Dumas;H. Guy
影响因子：
4.3
作者：
Rokkas, Theodoros;Pistiolas, Dimitrios;Koukoulis, Georgios
通讯作者：
Koukoulis, Georgios
影响因子：
5
作者：
SCHAPIRA, D;BENIZHAK, O;BEST, LA
通讯作者：
BEST, LA