Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions.
Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions.
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DOI：
10.3390/ph15050519
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发表时间：
2022-04-23
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影响因子：
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线粒体是雄性配子中结构和功能独特的细胞器。线粒体作为成熟精子中仅存的细胞器，不仅通过氧化磷酸化（oxidative phosphorylation，OXPHOS）产生三磷酸腺苷（adeno-sine triphosphate，ATP）支持精子运动，而且在调节活性氧化物质（reactive oxidation species，ROS）信号、钙稳态、类固醇激素合成和细胞凋亡等方面发挥重要作用。线粒体功能障碍通常与衰老过程有关。附睾的线粒体依赖性改变可导致精子线粒体功能的改变。由此产生的精子细胞缺陷与男性不育有关。其中，氧化应激（OS）由于在线粒体中的ROS的过度生产可能是这些疾病的主要原因之一。过量的ROS可引发DNA损伤，扰乱钙稳态，损害OXPHOS，破坏精子脂质膜的完整性，并诱导细胞凋亡。鉴于这些事实，通过抗氧化剂清除ROS在寻找治疗男性不育症的有希望的治疗策略方面具有巨大的潜力。在这里，我们总结了在理解线粒体功能障碍，衰老和男性不育方面取得的进展。抗氧化剂干预的临床潜力也进行了讨论。
Mitochondria are structurally and functionally unique organelles in male gametes. Apparently, as the only organelles remaining in mature sperm, mitochondria not only produce adeno-sine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) to support sperm mobility, but also play key roles in regulating reactive oxidation species (ROS) signaling, calcium homeostasis, steroid hormone biosynthesis, and apoptosis. Mitochondrial dysfunction is often associated with the aging process. Age-dependent alterations of the epididymis can cause alterations in sperm mitochondrial functioning. The resultant cellular defects in sperm have been implicated in male infertility. Among these, oxidative stress (OS) due to the overproduction of ROS in mitochondria may represent one of the major causes of these disorders. Excessive ROS can trigger DNA damage, disturb calcium homeostasis, impair OXPHOS, disrupt the integrity of the sperm lipid membrane, and induce apoptosis. Given these facts, scavenging ROS by antioxidants hold great potential in terms of finding promising therapeutic strategies to treat male infertility. Here, we summarize the progress made in understanding mitochondrial dysfunction, aging, and male infertility. The clinical potential of antioxidant interventions was also discussed.
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DOI：
10.5534/wjmh.200196
发表时间：
2021-04
期刊：
The world journal of men's health
影响因子：
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作者：
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20.1
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影响因子：
4.4
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Alshahrani, Saad;Agarwal, Ashok;Sabanegh, Edmund
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DOI：
10.3390/antiox11020306
发表时间：
2022-02-02
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
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通讯作者：
Gharagozloo P