Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
复制标题
DOI：
10.3346/jkms.2011.26.9.1132
复制
发表时间：
2011-09
影响因子：
4.5
通讯作者：
Min JK
中科院分区：
文献类型：
--
作者：
Hong YS;Moon SJ;Joo YB;Jeon CH;Cho ML;Ju JH;Oh HJ;Heo YJ;Park SH;Kim HY;Min JK
白介素33(IL-33)/ST2通路是一种细胞间信号系统，参与抗原-变态反应、自身免疫和纤维化。IL-33及其受体定位于类风湿关节炎滑膜，提示IL-33/ST2信号通路参与了类风湿关节炎的发病过程。本研究的目的是测定类风湿关节炎患者血清和滑液中IL-33和Sst2的水平。RA患者血清IL-33水平(294.9±464.0 pg/m L)显著高于健康对照组(96.0±236.9 pg/m L，P=0.002)。RA患者滑液中IL-33水平明显高于骨性关节炎患者。RA患者血清Sst2水平明显高于正常对照组(P=0.042)。81例RA患者IL-33与IL-1β水平(r=0.311，P=0.005)、IL-33与IL-6水平(r=0.264，P=0.017)呈正相关。10例初治RA患者经常规抗风湿药物治疗后，IL-33、Sst2和C-反应蛋白水平下降。结论：IL-33参与了类风湿关节炎的发病过程，可反映类风湿关节炎患者的炎症程度。
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.
登录
查看更多内容
DOI：
10.1073/pnas.0812690106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Cayrol, Corinne;Girard, Jean-Philippe
通讯作者：
Girard, Jean-Philippe
影响因子：
4.9
作者：
Cavanagh LL;Boyce A;Smith L;Padmanabha J;Filgueira L;Pietschmann P;Thomas R
通讯作者：
Thomas R
影响因子：
4.4
作者：
Leung, BP;Xu, D;Liew, FY
通讯作者：
Liew, FY
影响因子：
3.9
作者：
Mu, Rong;Huang, He-Qing;Li, Zhan-Guo
通讯作者：
Li, Zhan-Guo
影响因子：
4.9
作者：
Raza K;Falciani F;Curnow SJ;Ross EJ;Lee CY;Akbar AN;Lord JM;Gordon C;Buckley CD;Salmon M
通讯作者：
Salmon M