Acute effects of delta-9-tetrahydrocannabinol on performance monitoring in healthy volunteers.
Acute effects of delta-9-tetrahydrocannabinol on performance monitoring in healthy volunteers.
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DOI：
10.3389/fnbeh.2011.00059
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发表时间：
2011
影响因子：
3
通讯作者：
de Bruijn ER
中科院分区：
文献类型：
--
作者：
Spronk D;Dumont GJ;Verkes RJ;de Bruijn ER
基本原理：错误相关负波(ERN)是一种在错误反应后立即出现的负性事件相关电位，被认为反映了人类的表现监控。在健康志愿者中使用Delta-9-四氢大麻酚(THC)与行为研究中的行为监控受损有关，但到目前为止还没有研究考察大麻类物质对ERN的影响。方法：采用随机双盲交叉设计，记录10名健康志愿者在服用THC或安慰剂蒸气后执行快速选择反应时间任务(侧翼任务)时的脑电数据。结果：THC给药后ERN明显减少。侧翼任务的行为结果显示没有药物诱导的损伤迹象。讨论：ERN的减少反映了业绩监测过程中的损害。任务设计没有经过优化以发现行为影响。研究表明，大麻类物质损害了绩效监测。
Rationale: The error-related negativity (ERN) is a negative event-related potential that occurs immediately after an erroneous response and is thought to reflect human performance monitoring. Delta-9-Tetrahydrocannabinol (THC) administration in healthy volunteers has been linked to impaired performance monitoring in behavioral studies, but to date no studies have examined the effects of cannabinoids on the ERN. Methods: EEG data from 10 healthy volunteers was recorded during execution of a speeded choice-reaction-time task (Flankers task) after administration of THC or placebo vapor in a double-blind randomized crossover design. Results: The findings of this study show that the ERN was significantly reduced after administration of THC. The behavioral outcomes on the Flankers task showed no indications of drug-induced impairments. Discussion: The diminished ERN reflects impairments in the process of performance monitoring. The task design was not optimized to find behavioral effects. The study shows that cannabinoids impair performance monitoring.
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