Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine.
Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine.
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DOI：
10.1007/s00213-009-1756-4
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发表时间：
2010-03
影响因子：
3.4
通讯作者：
Nader, Michael A.
中科院分区：
文献类型：
--
作者：
Czoty, Paul W.;Gage, H. Donald;Nader, Michael A.
对群居猴子的研究表明，在社会支配等级中的地位对大脑多巴胺D2受体的影响，以及可卡因的强化效应，这种效应在长期自我服用可卡因后消散。这项研究的目的是研究在群居的猴子中，戒掉可卡因对D2受体的影响，并将行为特征扩展到对新事物的反应性测量。选取12只具有丰富的可卡因自我给药经验的雄性食蟹猴（优势猴和从属猴的平均终生摄入量分别为270和215 mg/kg）。禁欲持续约8个月，之后使用正电子发射断层扫描和D2配体[18F]氟氯硼化物评估D2受体的可用性。研究人员还评估了这些受试者以及9只单独饲养的猴子对新鲜事物的反应。在戒断期间，显性猴尾状核D2受体的可用性明显高于从属猴。与下属或单独饲养的猴子相比，占主导地位的猴子接触新物体的平均延迟时间也明显更高。在有社会经验的猴子中，尾状核D2受体的可用性与接触新物体的潜伏期之间存在显著的正相关。虽然长期的可卡因自我服用削弱了社会支配改变D2受体可用性和对可卡因强化效应敏感性的能力，但这种影响在戒断期间再次出现。此外，数据表明，先前的社会支配经验会导致对新奇事物的反应延迟更长——这是一种与可卡因滥用的低脆弱性相关的人格特征。
Studies in socially housed monkeys have demonstrated an influence of position in the social dominance hierarchy on brain dopamine D2 receptors and the reinforcing effects of cocaine that dissipates after long-term cocaine self-administration. The aims of the study were to examine the effects of abstinence from cocaine on D2 receptors in socially housed monkeys and to extend behavioral characterizations to measures of reactivity to a novel object. Twelve socially housed male cynomolgus monkeys with extensive cocaine self-administration experience were used (average lifetime intakes ~270 and 215 mg/kg for dominant and subordinate monkeys, respectively). Abstinence lasted for approximately 8 months, after which D2 receptor availability was assessed using positron emission tomography and the D2 ligand [18F]fluoroclebopride. Reaction to novelty was also assessed in these subjects as well as nine individually housed monkeys. During abstinence, D2 receptor availability in the caudate nucleus was significantly higher in dominant versus subordinate monkeys. Average latency to touch a novel object was also significantly higher in dominant monkeys compared to subordinates or individually housed monkeys. In socially experienced monkeys, a significant positive correlation was observed between caudate nucleus D2 receptor availability and latencies to touch the novel object. Although chronic cocaine self-administration blunts the ability of social dominance to alter D2 receptor availability and sensitivity to the reinforcing effects of cocaine, this influence reemerges during abstinence. In addition, the data suggest that prior experience with social dominance can lead to longer latencies in reaction to novelty—a personality trait associated with low vulnerability to cocaine abuse.
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影响因子：
56.9
作者：
PIAZZA, PV;DEMINIERE, JM;SIMON, H
通讯作者：
SIMON, H
影响因子：
2.3
作者：
Czoty, PW;Gage, HD;Nader, MA
通讯作者：
Nader, MA
影响因子：
3.2
作者：
Czoty PW;Gould RW;Nader MA
通讯作者：
Nader MA
影响因子：
7.3
作者：
MACH, RH;LUEDTKE, RR;EHRENKAUFER, RL
通讯作者：
EHRENKAUFER, RL
影响因子：
3.1
作者：
MACH, RH;ELDER, ST;EHRENKAUFER, RLE
通讯作者：
EHRENKAUFER, RLE