Relationship between social rank and cortisol and testosterone concentrations in male cynomolgus monkeys (Macaca fascicularis).
Relationship between social rank and cortisol and testosterone concentrations in male cynomolgus monkeys (Macaca fascicularis).
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DOI：
10.1111/j.1365-2826.2008.01800.x
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发表时间：
2009-01
影响因子：
3.2
通讯作者：
Nader MA
中科院分区：
文献类型：
--
作者：
Czoty PW;Gould RW;Nader MA
在非人类灵长类社会群体中，与社会地位相关的生物学差异已被证明有助于研究对各种疾病状态的敏感性机制。在慢性社会压力的背景下，主导和从属猴子之间的生理和神经生物学差异已被解释。本实验旨在研究基础皮质醇和睾酮浓度与雄性食蟹猴社会等级的建立和维持之间的关系。皮质醇浓度测量基线和地塞米松（DEX）抑制后，随后给予ACTH，而猴子单独圈养（n=20）和3个月后的社会住房（n=4/组），到该时间的优势层次已经稳定。在社会住房的最初三天也测量了皮质醇。无论是前社会住房激素浓度和HPA轴的敏感性预测最终的社会地位。在最初的社会住房，皮质醇浓度显着较高的猴子，最终成为下属;这种影响在三天内消失。在12周的社会住房期间，一直观察到攻击性和顺从性行为，形成了社会等级分配的基础。在这个时候，基础睾酮和皮质醇浓度显着较高的占主导地位的猴子，地塞米松抑制后，皮质醇释放响应于挑战注射促肾上腺皮质激素显着更大的下属。这些结果表明，基础皮质醇和睾酮浓度和HPA轴功能的状态变量，差异反映的优势层次结构中的位置，而不是性状变量，预测未来的社会地位。
In nonhuman primate social groups, biological differences related to social status have proven useful in investigating mechanisms of sensitivity to various disease states. Physiological and neurobiological differences between dominant and subordinate monkeys have been interpreted in the context of chronic social stress. The present experiments were designed to investigate the relationships between basal cortisol and testosterone concentrations and the establishment and maintenance of the social hierarchy in male cynomolgus monkeys. Cortisol concentrations were measured at baseline and following suppression with dexamethasone (DEX) and subsequent administration of ACTH while monkeys were individually housed (n=20) and after 3 months of social housing (n=4/group), by which time dominance hierarchies had stabilised. Cortisol was also measured during the initial three days of social housing. Neither pre-social housing hormone concentrations nor HPA axis sensitivity predicted eventual social rank. During initial social housing, cortisol concentrations were significantly higher in monkeys that eventually became subordinate; this effect dissipated within three days. During the 12 weeks of social housing, aggressive and submissive behaviours were observed consistently, forming the basis for assignment of social ranks. At this time, basal testosterone and cortisol concentrations were significantly higher in dominant monkeys and, following dexamethasone suppression, cortisol release in response to a challenge injection of ACTH was significantly greater in subordinates. These results indicate that basal cortisol and testosterone concentrations and HPA axis function are state variables that differentially reflect position in the dominance hierarchy, rather than trait variables that predict future social status.
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