Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: a combined ERP and DTI study.
Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: a combined ERP and DTI study.
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DOI：
10.1016/j.neuroimage.2010.10.048
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发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Spencer KM
中科院分区：
文献类型：
--
作者：
Whitford TJ;Kubicki M;Ghorashi S;Schneiderman JS;Hawley KJ;McCarley RW;Shenton ME;Spencer KM
精神分裂症的几种理论强调了异常神经时序在疾病病因中的作用，可能是由于白质纤维束的结构损伤引起的传导延迟。与这一理论相一致，增加半球间传输时间（IHTTs），以单边提出的视觉刺激已被报道在精神分裂症患者。本研究调查这些IHTT异常是否可以通过胼胝体视觉纤维的结构损伤来支持。对30例精神分裂症患者和22例对照者进行事件相关电位（ERP）记录，并对19例患者和16例对照者进行3 T弥散张量成像（DTI）。单侧视觉刺激（正方形，2 × 2度）呈现为中央注视点两侧6度外侧。在电流源密度转换的ERP中，计算枕-颞部位P1和N1分量的IHTT（同侧减去对侧LATERAL）。应用流线型纤维束成像技术提取胼胝体视纤维，计算各向异性分数（FA）和模式（Mode）的弥散度。虽然两个受试者组在一系列后部电极对上均表现出高度显著的IHTT，并且从左到右半球的IHTT显著短于从右到左半球的IHTT，但未观察到IHTT的显著分组差异。然而，参与者的IHTT与他们的FA和众数呈线性相关，较长的IHTT与较低的FA和较长的扩散椭圆体相关。这些结果表明，IHTT是估计的白色物质完整性的DTI措施。根据精神分裂症患者中已报告的弥散异常范围，特别是额束，这些结果支持了精神分裂症最终由神经计时异常支撑的推测。
Several theories of schizophrenia have emphasized the role of aberrant neural timing in the etiology of the disease, possibly as a consequence of conduction delays caused by structural damage to the white-matter fasciculi. Consistent with this theory, increased inter-hemispheric transmission times (IHTTs) to unilaterally-presented visual stimuli have been reported in patients with schizophrenia. The present study investigated whether or not these IHTT abnormalities could be underpinned by structural damage to the visual fibers of the corpus callosum. 30 schizophrenia patients and 22 matched controls underwent Event Related Potential (ERP) recording, and a subset of 19 patients and 16 controls also underwent 3T Diffusion-Tensor Imaging (DTI). Unilateral visual stimuli (squares, 2 × 2 degrees) were presented 6 degrees lateral to either side of a central fixation point. IHTTs (ipsilateral minus contralateral latencies) were calculated for the P1 and N1 components at occipital-temporal sites in current source density-transformed ERPs. The visual fibers of the corpus callosum were extracted with streamline tractography and the diffusion metrics of Fractional Anisotropy (FA) and Mode calculated. While both subject groups exhibited highly significant IHTTs across a range of posterior electrode pairs, and significantly shorter IHTTs from left-to-right hemisphere than vice versa, no significant groupwise differences in IHTT were observed. However, participants’ IHTTs were linearly related to their FA and Mode, with longer IHTTs being associated with lower FA and more prolate diffusion ellipsoids. These results suggest that IHTTs are estimable from DTI measures of white matter integrity. In light of the range of diffusion abnormalities that have been reported in patients with schizophrenia, particularly in frontal fasciculi, these results support the conjecture that schizophrenia is ultimately underpinned by abnormalities in neural timing.
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