Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19.
Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19.
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DOI：
10.1016/j.ynstr.2021.100326
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发表时间：
2021-05
影响因子：
5
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
Duan K;Premi E;Pilotto A;Cristillo V;Benussi A;Libri I;Giunta M;Bockholt HJ;Liu J;Campora R;Pezzini A;Gasparotti R;Magoni M;Padovani A;Calhoun VD
COVID-19是由最近发现的严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的传染病，已成为全球大流行病。它极大地影响了人们的健康和日常生活。神经系统并发症在COVID-19患者中越来越多。然而，COVID-19对大脑的影响研究较少，现有的COVID-19定量神经成像分析主要基于单变量基于体素的形态测量分析（VBM），该分析需要对大量的统计显著性检验进行校正，可以减少校正检验数量的多变量方法尚未应用于研究COVID-19对大脑的影响。在这项研究中，我们利用基于源的形态测量学（SBM）分析（VBM的多变量扩展）来识别120名神经系统患者（包括年龄、性别和疾病匹配的58名COVID-19患者和62名非COVID-19患者）中COVID-19相关的计算机断层扫描中的变化。SBM发现，即使在控制脑血管疾病的情况下，在出院和6个月随访阶段，额上级/内侧/中间回的较低灰质体积（GMV）与较高的残疾水平（改良兰金量表）显著相关。与未接受氧疗的患者相比，接受氧疗的患者的上级/内侧/中额回的GMV也显著降低。与不发烧的患者相比，发烧患者颞下回/中回和梭状回的GMV显着降低。与无激越的患者相比，激越患者的上级/内侧/额中回GMV降低。COVID-19患者与非COVID-19患者在任何脑区的GMV均无显著差异。结果表明，COVID-19可能通过发热或缺氧以继发方式影响额颞网络。我们使用基于源的形态测量法确定了COVID-19潜在的灰质改变。额叶灰质体积（GMV）较低与更严重的残疾有关。接受氧气治疗的患者在广泛的额叶区域GMV较低。发热患者表现为颞回和梭状回GMV降低。
COVID-19, the infectious disease caused by the most recently discovered severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a global pandemic. It dramatically affects people's health and daily life. Neurological complications are increasingly documented for patients with COVID-19. However, the effect of COVID-19 on the brain is less studied, and existing quantitative neuroimaging analyses of COVID-19 were mainly based on the univariate voxel-based morphometry analysis (VBM) that requires corrections for a large number of tests for statistical significance, multivariate approaches that can reduce the number of tests to be corrected have not been applied to study COVID-19 effect on the brain yet. In this study, we leveraged source-based morphometry (SBM) analysis, a multivariate extension of VBM, to identify changes derived from computed tomography scans in covarying gray matter volume patterns underlying COVID-19 in 120 neurological patients (including 58 cases with COVID-19 and 62 patients without COVID-19 matched for age, gender and diseases). SBM identified that lower gray matter volume (GMV) in superior/medial/middle frontal gyri was significantly associated with a higher level of disability (modified Rankin Scale) at both discharge and six months follow-up phases even when controlling for cerebrovascular diseases. GMV in superior/medial/middle frontal gyri was also significantly reduced in patients receiving oxygen therapy compared to patients not receiving oxygen therapy. Patients with fever presented significant GMV reduction in inferior/middle temporal gyri and fusiform gyrus compared to patients without fever. Patients with agitation showed GMV reduction in superior/medial/middle frontal gyri compared to patients without agitation. Patients with COVID-19 showed no significant GMV differences from patients without COVID-19 in any brain region. Results suggest that COVID-19 may affect the frontal-temporal network in a secondary manner through fever or lack of oxygen. We identified gray matter alterations underlying COVID-19 using source-based morphometry. Lower gray matter volume (GMV) in frontal regions linked to more severe disability. Patients receiving oxygen therapy had lower GMV in widespread frontal regions. Patients with fever presented reduced GMV in temporal and fusiform gyri.
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