Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition.
Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition.
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DOI：
10.1016/j.pscychresns.2012.05.002
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发表时间：
2013-01-30
影响因子：
11.3
通讯作者：
McClernon FJ
中科院分区：
文献类型：
--
作者：
Froeliger B;Modlin LA;Kozink RV;Wang L;Garland EL;Addicott MA;McClernon FJ
戒烟引起的情感和认知破坏与前额叶功能失调有关，尽管人们对吸烟者与不吸烟者情感认知过程中差异的神经灶知之甚少。因此，当前的研究利用功能磁共振成像来识别吸烟者与不吸烟者在情感认知方面的差异。 34 名健康志愿者（17 名吸烟者，17 名不吸烟者）在情感斯特鲁普任务 (aST) 中接受了功能磁共振成像 (fMRI)。 aST 包括情绪线索反应试验和包含中性或消极情绪干扰因素的反应选择试验。在负提示反应性试验中，吸烟者在支持情绪意识（即后扣带回）、抑制控制（即额下回）和冲突解决（即前扣带回）的区域中的激活程度较低；而在使用负面情绪干扰因素的反应选择试验中，吸烟者的额顶注意力网络（即额中回和边缘上回）有更大的激活。探索性分析表明，任务准确性与 ACC 和 IFG BOLD 反应呈正相关。这些发现表明，长期使用尼古丁可能会降低情绪分心的抑制控制和冲突解决，并导致在情绪干扰认知期间招募额外的注意力资源。
Smoking withdrawal-induced disruption of affect and cognition is associated with dysregulated prefrontal brain function although little is known regarding the neural foci of smoker-nonsmoker differences during affective cognition. Thus, the current study utilized fMRI to identify smoker-nonsmoker differences in affective cognition. Thirty-four healthy volunteers (17 smokers, 17 nonsmokers) underwent fMRI during an affective Stroop task (aST). The aST includes emotional cue-reactivity trials, and response selection trials that contain either neutral or negative emotional distractors. Smokers had less activation during negative cue-reactivity trials in regions subserving emotional awareness (i.e. posterior cingulate), inhibitory control (i.e. inferior frontal gyrus) and conflict resolution (i.e. anterior cingulate); whereas during response selection trials with negative emotional distractors, smokers had greater activation in a frontoparietal attentional network (i.e. middle frontal and supramarginal gyri). Exploratory analyses revealed that task accuracy was positively correlated with ACC and IFG BOLD response. These findings suggests that chronic nicotine use may reduce inhibitory control and conflict resolution of emotional distraction, and result in recruiting additional attentional resources during emotional interference on cognition.
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影响因子：
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作者：
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