Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: prospective cohort study.
Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: prospective cohort study.
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DOI：
10.1136/bmj.g2472
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发表时间：
2014-04-29
期刊：
影响因子：
--
通讯作者：
Chang RW
中科院分区：
文献类型：
--
作者：
Dunlop DD;Song J;Semanik PA;Sharma L;Bathon JM;Eaton CB;Hochberg MC;Jackson RD;Kwoh CK;Mysiw WJ;Nevitt MC;Chang RW
Objective To investigate whether objectively measured time spent in light intensity physical activity is related to incident disability and to disability progression. Design Prospective multisite cohort study from September 2008 to December 2012. Setting Baltimore, Maryland; Columbus, Ohio; Pittsburgh, Pennsylvania; and Pawtucket, Rhode Island, USA. Participants Disability onset cohort of 1680 community dwelling adults aged 49 years or older with knee osteoarthritis or risk factors for knee osteoarthritis; the disability progression cohort included 1814 adults. Main outcome measures Physical activity was measured by accelerometer monitoring. Disability was ascertained from limitations in instrumental and basic activities of daily living at baseline and two years. The primary outcome was incident disability. The secondary outcome was progression of disability defined by a more severe level (no limitations, limitations to instrumental activities only, 1-2 basic activities, or ≥3 basic activities) at two years compared with baseline. Results Greater time spent in light intensity activities had a significant inverse association with incident disability. Less incident disability and less disability progression were each significantly related to increasing quartile categories of daily time spent in light intensity physical activities (hazard ratios for disability onset 1.00, 0.62, 0.47, and 0.58, P for trend=0.007; hazard ratios for progression 1.00, 0.59, 0.50, and 0.53, P for trend=0.003) with control for socioeconomic factors (age, sex, race/ethnicity, education, income) and health factors (comorbidities, depressive symptoms, obesity, smoking, lower extremity pain and function, and knee assessments: osteoarthritis severity, pain, symptoms, prior injury). This finding was independent of time spent in moderate-vigorous activities. Conclusion These prospective data showed an association between greater daily time spent in light intensity physical activities and reduced risk of onset and progression of disability in adults with osteoarthritis of the knee or risk factors for knee osteoarthritis. An increase in daily physical activity time may reduce the risk of disability, even if the intensity of that additional activity is not increased.
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DOI：
10.1136/bmj.e2758
发表时间：
2012-06-06
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Chalder M;Wiles NJ;Campbell J;Hollinghurst SP;Haase AM;Taylor AH;Fox KR;Costelloe C;Searle A;Baxter H;Winder R;Wright C;Turner KM;Calnan M;Lawlor DA;Peters TJ;Sharp DJ;Montgomery AA;Lewis G
通讯作者：
Lewis G
DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
DOI：
10.1136/bmj.e70
发表时间：
2012-01-30
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Fong DY;Ho JW;Hui BP;Lee AM;Macfarlane DJ;Leung SS;Cerin E;Chan WY;Leung IP;Lam SH;Taylor AJ;Cheng KK
通讯作者：
Cheng KK
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
120.7
作者：
Church, Timothy S.;Earnest, Conrad P.;Blair, Steven N.
通讯作者：
Blair, Steven N.