Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers.
Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers.
复制标题
DOI：
10.1007/s00213-006-0515-z
复制
发表时间：
2006-10
影响因子：
3.4
通讯作者：
Sahakian, Barbara J.
中科院分区：
文献类型：
--
作者：
Ersche, Karen D.;Fletcher, Paul C.;Roiser, Jonathan P.;Fryer, Tim D.;London, Mervyn;Robbins, Trevor W.;Sahakian, Barbara J.
关键词：
此前，我们报道过，与海洛因使用者和健康志愿者相比，参加美沙酮治疗的阿片类药物使用者在失分后在决策任务上做出了“危险”的选择。对这种行为的一个可能的解释是，美沙酮使用者对之前不成功的试验的惩罚不太敏感。我们试图通过对之前的正电子发射断层扫描研究的数据进行事后分析，从神经角度探索这一发现。我们将分析限制在阿片类药物组和对照组，评估使用美沙酮的阿片类药物使用者和使用海洛因的阿片类药物使用者之间的差异。我们发现，与海洛因使用者和对照组相比，美沙酮使用者的外侧眶额皮质 (OFC) 显着过度激活，总体上“冒险”的倾向最大。与其他两组相比，海洛因使用者在这一领域表现出显着的激活不足，同时表现出最大的“安全行事”总体倾向。相关分析显示，左 OFC 异常任务相关激活与美沙酮使用者的美沙酮剂量以及海洛因使用者静脉注射海洛因的持续时间有关。在对照组中，失分后的“谨慎行事”也与前扣带回和岛叶皮质的激活呈负相关，但在阿片类药物使用者中则不然。我们的研究结果表明，为了选择反应而整合惩罚信息所涉及的过程之间的相互作用可能会在阿片类药物使用者中发生改变。这种变化在 OFC 激活的任务相关模式中有所不同，具体取决于所使用的阿片类药物。
Previously, we reported that opiate users enrolled in methadone treatment made ‘risky’ choices on a decision-making task following a loss of points compared with heroin users and healthy volunteers. One possible explanation for this behaviour is that methadone users were less sensitive to punishment on immediately preceding unsuccessful trials. We sought to explore this finding from a neural perspective by performing a post hoc analysis of data from a previous positron emission tomography study. We restricted the analysis to the opiate groups and controls, assessing differences between opiate users on methadone and those on heroin. We found significant over-activation in the lateral orbitofrontal cortex (OFC) in methadone users compared with both heroin users and controls concomitant with the greatest overall tendency to ‘play risky’. Heroin users showed significant under-activation in this area compared with the other two groups whilst exhibiting the greatest overall tendency to ‘play safe’. Correlational analysis revealed that abnormal task-related activation of the left OFC was associated with the dose of methadone in methadone users and with the duration of intravenous heroin use in heroin users. ‘Playing safe’ following a loss of points was also negatively correlated with the activation of pregenual anterior cingulate and insula cortex in controls, but not in opiate users. Our findings suggest that the interplay between processes involved in integrating penalty information for the purpose of response selection may be altered in opiate users. This change was reflected differentially in task-related pattern of OFC activation depending on the opiate used.
登录
查看更多内容
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
2.3
作者：
Brady, TA;Salvucci, S;Yu, P
通讯作者：
Yu, P
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.3
作者：
Blair, HT;Sotres-Bayon, F;Ledoux, JE
通讯作者：
Ledoux, JE
影响因子：
17.7
作者：
Liotti, M;Mayberg, HS;Jerabek, P
通讯作者：
Jerabek, P